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Could Ultrasound Elastography Reflect Liver Function?

Tingting Qiu1, Hong Wang1, Jinzhen Song1

  • 1Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, China.

Ultrasound in Medicine & Biology
|February 7, 2018
PubMed
Summary
This summary is machine-generated.

Ultrasound elastography, measuring liver stiffness, shows a strong correlation with liver function reserve. This non-invasive technique may help assess liver health across various fibrosis stages.

Keywords:
Indocyanine green elimination testLiver fibrosisLiver function reserveLiver stiffnessPoint shear wave elastography

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Area of Science:

  • Hepatology
  • Medical Imaging
  • Diagnostic Technologies

Background:

  • Liver fibrosis is a significant health concern, often assessed invasively.
  • Non-invasive methods for evaluating liver function reserve are crucial for patient management.
  • Ultrasound elastography offers a potential non-invasive approach to assess liver stiffness.

Purpose of the Study:

  • To determine if ultrasound elastography (liver stiffness value, LSV) correlates with liver function reserve, assessed by the indocyanine green (ICG) elimination test (ICGR15).
  • To investigate the relationship between liver stiffness and histological liver fibrosis stages (F0-F4).

Main Methods:

  • Sixty-five rabbits underwent induced liver fibrosis (F1-F4) using carbon tetrachloride.
  • Point shear wave elastography and ICG elimination tests were performed over 56 weeks.
  • Correlation analysis was conducted between liver stiffness values (LSV) and ICG retention rates at 15 minutes (ICGR15).

Main Results:

  • Significant differences in LSV and ICGR15 were observed across fibrosis stages (p < 0.01).
  • Median LSVs ranged from 3.92 kPa (F0) to 16.64 kPa (F4).
  • Median ICGR15 values increased from 8.7% (F0) to 45.6% (F4), showing a strong positive correlation with LSV (r = 0.7497, p < 0.0001).

Conclusions:

  • Ultrasound elastography, measured by LSV, strongly correlates with liver function reserve (ICGR15).
  • This indicates that ultrasound elastography can effectively reflect liver function reserve in the context of varying degrees of liver fibrosis.
  • Ultrasound elastography presents a promising non-invasive tool for assessing liver health and function.