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Updated: Feb 14, 2026

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents
Published on: September 16, 2020
Ocriplasmin retinopathy: Possible cause of macular hole closure failure
P Udaondo1, A Barreiro-González1, S García-Delpech1
1Servicio de Oftalmología, Hospital Universitario y Politécnico La Fe, Valencia, España.
Case Report:
A 53 year-old woman with a stage 2 macular hole received ocriplasmin injection as a first approach. She subsequently underwent pars plana vitrectomy due to enlargement of the hole post-injection. The visual gain following the surgery was minimal despite closure of the hole. This could be explained by outer retina atrophy as a consequence of potential toxic mechanisms related to ocriplasmin.
Discussion:
Further studies may be warranted to fully understand the impact of ocriplasmin on long-term visual function.
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