Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Potential Energy00:52

Potential Energy

43.0K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
43.0K
Potential Energy01:09

Potential Energy

1.0K
A conservative force, such as a gravitational or elastic force, gives the body the capacity to do work. This capacity, measured as the potential energy, depends on the body's location or “position” relative to a fixed reference position or datum. The gravitational potential energy is considered zero at the reference point. Suppose a body is located at some vertical distance above a fixed horizontal reference or datum. In that case, the weight of the body has positive gravitational potential...
1.0K
Standard Electrode Potentials03:02

Standard Electrode Potentials

50.6K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.6K
Cell Potential and Free Energy02:58

Cell Potential and Free Energy

46.8K
Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
46.8K
The Resting Membrane Potential01:21

The Resting Membrane Potential

143.4K
Overview
143.4K
Electric Potential and Potential Difference01:16

Electric Potential and Potential Difference

5.8K
Suppose a positive test charge moves away from a positive static charge, then the Coulomb force does positive work, and its electric potential energy decreases. The potential energy per unit charge is defined as the electric potential. The electric potential is independent of the test charge.
When a test charge moves from the initial to the final position, the electric potential difference between those positions is defined as the ratio of the change in the potential energy to the charge on the...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Needle immersed vitrification can lower the concentration of cryoprotectant in human ovarian tissue cryopreservation.

Fertility and sterility·2010
Same author

Maternal control of early mouse development.

Development (Cambridge, England)·2010
Same author

Characterization of EndoTT, a novel single-stranded DNA-specific endonuclease from Thermoanaerobacter tengcongensis.

Nucleic acids research·2010
Same author

Association study between three polymorphisms and myocardial infarction and ischemic stroke in Chinese Han population.

Thrombosis research·2010
Same author

Arabidopsis IWS1 interacts with transcription factor BES1 and is involved in plant steroid hormone brassinosteroid regulated gene expression.

Proceedings of the National Academy of Sciences of the United States of America·2010
Same author

Effect of isoflavone extracts from glycine max on human endothelial cell damage and on nitric oxide production.

Menopause (New York, N.Y.)·2010

Related Experiment Video

Updated: Feb 14, 2026

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors
15:24

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Published on: December 16, 2022

4.0K

A CYP2B6-humanized mouse model and its potential applications.

Lei Li1, Qing-Yu Zhang2, Xinxin Ding2

  • 1Wadsworth Center, New York State Department of Health, School of Public Health, State University of New York at Albany, NY, 12201, USA.

Drug Metabolism and Pharmacokinetics
|February 7, 2018
PubMed
Summary
This summary is machine-generated.

A humanized mouse model expressing human CYP2B6 offers a valuable tool for studying drug metabolism and toxicity. This model aids research into drug interactions and efficacy by mimicking human CYP2B6 activity.

Keywords:
CYP2B6Drug metabolismHumanized miceKnockout miceLiverXenobiotic toxicity

More Related Videos

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

10.7K
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

5.3K

Related Experiment Videos

Last Updated: Feb 14, 2026

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors
15:24

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Published on: December 16, 2022

4.0K
Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

10.7K
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

5.3K

Area of Science:

  • Pharmacology
  • Toxicology
  • Genetics

Background:

  • Cytochrome P450 2B6 (CYP2B6) is a key human enzyme in drug metabolism.
  • Rodent models often have multiple functional Cyp2b genes, unlike humans who have only one.

Purpose of the Study:

  • To review the utility of mouse models for studying CYP2B6.
  • To discuss the development and applications of a CYP2B6-humanized mouse model.

Main Methods:

  • Generation of a CYP2B6-humanized mouse model expressing human CYP2B6 in the liver.
  • Utilizing Cyp2b knockout/knockdown mouse models to understand in vivo roles.

Main Results:

  • The CYP2B6-humanized mouse model successfully expresses active human CYP2B6 in the liver.
  • The model demonstrates compatibility with mouse nuclear receptors for CYP2B induction.
  • This model is suitable for studying drug metabolism, efficacy, interactions, and toxicity.

Conclusions:

  • The CYP2B6-humanized mouse is a valuable preclinical model for drug development and safety assessment.
  • Further research can explore the applications and limitations of these models in xenobiotic studies.