Association between IL-13 Gene rs20541 Polymorphism and Glioma Susceptibility: A Meta-Analysis
Dong Yang1, Yue Yuan, Sixun Zhang
1China-Japan Friendship Hospital, Beijing, China.
Oncology Research and Treatment
|February 7, 2018
Summary
This meta-analysis suggests a weak link between the IL-13 gene rs20541 polymorphism and glioma risk. Associations differ between Asian and Caucasian populations, indicating potential ethnic variations in susceptibility.
Area of Science:
- Genetics
- Oncology
- Epidemiology
Background:
- Glioma is a primary brain tumor with complex etiology.
- Interleukin-13 (IL-13) gene polymorphisms have been investigated for their role in cancer susceptibility.
Purpose of the Study:
- To conduct a meta-analysis to evaluate the association between the IL-13 gene rs20541 (R130Q) polymorphism and glioma susceptibility.
- To explore potential ethnic differences in this association.
Main Methods:
- A systematic literature search was performed across major databases (PubMed, EMBASE, EBSCO, Ovid) for studies published before February 1, 2016.
- Meta-analysis was conducted using Stata 11.0 software, calculating odds ratios (ORs) and 95% confidence intervals (95% CIs).
- Included 10 case-control studies comprising 3,123 glioma cases and 5,390 controls.
Main Results:
- A significant increase in glioma susceptibility was observed in the dominant genetic model (AA + AG vs. GG: OR = 1.14, P = 0.031).
- In Asians, the IL-13 rs20541 polymorphism was associated with decreased glioma susceptibility (heterozygote: OR = 0.74, P = 0.042; allele contrast: OR = 0.67, P = 0.028).
- Conversely, in Caucasians, a significant increase in glioma susceptibility was found in the dominant model (OR = 1.25, P = 0.000).
Conclusions:
- The IL-13 gene rs20541 polymorphism may have a weak association with glioma susceptibility.
- The observed association between IL-13 rs20541 and glioma risk appears to be influenced by ethnicity.
Related Concept Videos
01:09Directing Effect of Substituents: meta-Directing Groups
6.1K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.1K
01:31Magnetic Susceptibility and Permeability
2.4K
In linear magnetic materials, like paramagnets and diamagnets, magnetization is proportional to the magnetic field intensity. The constant of proportionality, a dimensionless number, is called magnetic susceptibility. The value of the susceptibility depends on the type of material.
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
2.4K
02:07Organization of Genes
73.7K
Overview
73.7K
01:05Single Nucleotide Polymorphisms-SNPs
18.6K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.6K
01:10Carbon-13 (¹³C) NMR: Overview
7.8K
Carbon-13 is a naturally occurring NMR-active isotope of carbon with a low natural abundance of 1.1%. In contrast, carbon-12 is the most abundant isotope of carbon with zero nuclear spin. Therefore, it is NMR inactive. The gyromagnetic ratio of carbon-13 is smaller than that of protons. As a result, carbon-13 resonance is about 6000 times weaker than proton resonance. For a given magnetic field strength, the resonance frequency of carbon-13 is about one-fourth of the resonance frequency for...
7.8K
01:27Associative Learning
1.5K
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
Classical conditioning, also known...
1.5K