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Unrecognized Prevalence of Macrocytosis among the Patients with First Episode of Psychosis and Depression

Ramdas Sarjerao Ransing1, Suvarna Patil2, Krishna Pevekar1

  • 1Department of Psychiatry, B K L Walawalkar Rural Medical College, Ratnagiri, India.

Indian Journal of Psychological Medicine
|February 7, 2018
PubMed
Abstract

Insights

This study found higher rates of macrocytosis in first-episode depression and psychosis patients compared to controls. Macrocytosis may be important for understanding and treating these mental health conditions.

Area of Science:

  • Hematology
  • Psychiatry
  • Clinical Medicine

Background:

  • Macrocytosis has been linked to mood disorders and psychosis.
  • Prevalence of macrocytosis in first-episode depression and psychosis is not well-established.

Purpose of the Study:

  • To determine the prevalence of macrocytosis in patients experiencing their first episode of depression or psychosis.

Main Methods:

  • A cross-sectional study included 100 patients with first-episode depression, 100 with first-episode psychosis, and 100 healthy controls.
  • Automated coulter counter analysis of blood samples assessed hematological variables, including macrocytosis and anemia.
  • Chi-square and ANOVA tests compared variables across the three groups.

Main Results:

  • Macrocytosis prevalence was 8% in depression and 11% in psychosis, significantly higher than the 3% in healthy controls.
  • Hemoglobin concentration, mean corpuscular volume, and mean platelet volume differed significantly between patient groups and controls (P < 0.001).

Conclusions:

  • First-episode depression and psychosis patients exhibit a higher prevalence of macrocytosis than healthy individuals.
  • Macrocytosis may hold etiological and prognostic importance in these patient populations.
  • Further prospective research is recommended to clarify the clinical significance of macrocytosis in depression and psychosis.
Keywords:
Anemiadepressionmacrocytosisplatelet countpsychosis

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