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Thrombocytosis in children: Clinico-hematological profile from a single centre in Eastern India

Rachita Sarangi1, Sarita Pradhan2, Avantika Dhanawat1

  • 1Department of Paediatrics, IMS and Sum Hospital, Bhubaneswar, Odisha, India.

Journal of Laboratory Physicians
|February 7, 2018
PubMed

Insights

Thrombocytosis, an elevated platelet count, is common in children (10.8%), with infection being the primary cause of secondary thrombocytosis. Platelet indices like MPV and PDW decrease as platelet counts rise.

Area of Science:

  • Pediatric Hematology
  • Clinical Pathology

Background:

  • Thrombocytosis occurs in 6%-15% of hospitalized children.
  • Elevated platelet counts require etiological investigation in pediatric patients.

Purpose of the Study:

  • To determine the causes of thrombocytosis in children.
  • To analyze platelet parameters in pediatric thrombocytosis.

Main Methods:

  • Prospective observational study conducted over 6 months in a tertiary care center.
  • Included children aged 1-14 years undergoing complete blood counts (CBC).
  • Collected data on hemoglobin, red blood cell indices, and platelet indices (PDW, MPV, P-LCR).

Main Results:

  • Thrombocytosis identified in 10.8% of 2500 pediatric CBCs.
  • 99.6% of cases were secondary thrombocytosis; only one primary case.
  • Infection (39.5%) and iron deficiency anemia (14.1%) were the leading causes.
  • Significant inverse correlation observed between platelet count and MPV, P-LCR, and PDW (P < 0.05).

Conclusions:

  • Thrombocytosis is a frequent finding in pediatric patients (10.8%).
  • Secondary thrombocytosis is predominant, with infection as the most common etiology.
  • Platelet indices show significant changes with varying platelet counts in children.
Abstract

Keywords:
Platelet indicesprimarysecondarythrombocytosis

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