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Evaluation of renal function in subclinical hypothyroidism.
Vijayetha P Patil1, Alagilwada S Shilpasree1, Vidya S Patil1
1Department of Biochemistry, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India.
Journal of Laboratory Physicians
|February 7, 2018
Summary
Subclinical hypothyroidism (SCH) is linked to reduced kidney function, similar to overt hypothyroidism. Serum creatinine changes in SCH reflect underlying tissue hypothyroidism, impacting glomerular filtration rate (GFR).
Area of Science:
- Endocrinology
- Nephrology
- Internal Medicine
Background:
- Subclinical hypothyroidism (SCH) is a laboratory diagnosis with minimal symptoms.
- Overt hypothyroidism (OHT) is known to reduce glomerular filtration rate (GFR) and elevate serum creatinine.
- This study investigates if SCH also impacts kidney function.
Purpose of the Study:
- To determine the effect of SCH on kidney function.
- To correlate thyroid-stimulating hormone (TSH) with creatinine and estimated GFR (eGFR).
- To assess if TSH can predict creatinine levels in SCH.
Main Methods:
- A 1-year hospital-based cross-sectional study included 608 subjects.
- Participants were categorized into SCH, OHT, and euthyroid (ET) groups.
- TSH, creatinine, and eGFR were measured; eGFR was calculated using MDRD and CKD-EPI equations.
Main Results:
- SCH and OHT groups showed significantly higher serum creatinine and lower eGFR compared to the ET group (P < 0.001).
- A significant correlation between TSH, creatinine, and eGFR was observed only in the OHT group.
- Linear regression indicated TSH accounted for 44.5% of creatinine variation in OHT and 48.2% in SCH.
Conclusions:
- SCH patients exhibit biochemical similarities to OHT patients.
- Elevated serum creatinine in SCH reflects tissue hypothyroidism.
- Kidney function parameters are affected in SCH, mirroring overt disease.
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