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The clinicopathological features of patients with membranous nephropathy
Hanyu Zhu1, Qiuxia Han2, Dong Zhang1
1Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing Key Laboratory of Kidney Disease, Beijing, China.
Background:
Membranous nephropathy (MN) represents a distinct glomerular disease which has been considered as a major cause of nephrotic syndrome (NS) in adults. Evidences show that the clinicopathological features of MN are various among MN cases. This study aimed to summarize and analyze the clinicopathological features of patients with MN.
Methods:
A total of 231 MN patients were recruited in this study. Their clinical and pathological features were collected and analyzed according to their age, gender, pathological stages, and anti-phospholipase A2 receptor (anti-PLA2R) antibodies tests.
Results:
Among the 231 MN cases, the ratio of male to female was 1.47 and the mean age was 47.43±14.32 years. Altogether, 163 (70.6%) cases were positive for NS. Their serum antiPLA2R, body mass index, total cholesterol, triglyceride, low density lipoprotein cholesterol, D2, IgA, and IgE were increased, but IgG was decreased. The majority of the patients were middle aged and old aged. In addition, the pathological stage was significantly correlated with gender (P=0.038), creatinine, (P=0.021) and IgE (P=0.003). A total of 74.9% MN patients were found to be positive for anti-PLA2R antibodies, and they were more likely to have abnormal serum indices.
Conclusion:
The major clinicopathological characteristics of MN patients are summarized in this study. Male and elder MN cases are likely to have rapid disease progression. Advanced pathological stages and being positive for anti-PLA2R antibodies may be potential indicators for disease activity of MN.
Insights
This study analyzed 231 membranous nephropathy (MN) patients, finding male and older individuals often experience rapid disease progression. Advanced stages and positive anti-phospholipase A2 receptor (anti-PLA2R) antibodies indicate higher disease activity.
Area of Science:
- Nephrology
- Glomerular Diseases
- Internal Medicine
Background:
- Membranous nephropathy (MN) is a key cause of nephrotic syndrome in adults.
- Clinicopathological features of MN exhibit significant variability.
- Understanding these features is crucial for patient management.
Purpose of the Study:
- To summarize and analyze the clinicopathological features of patients diagnosed with MN.
- To identify factors associated with disease progression and activity.
Main Methods:
- Retrospective analysis of 231 MN patients.
- Data collected included age, gender, pathological stages, and anti-phospholipase A2 receptor (anti-PLA2R) antibody status.
- Statistical analysis of clinical and pathological data.
Main Results:
- The study included 231 MN patients (male:female ratio 1.47, mean age 47.43±14.32 years).
- Nephrotic syndrome (NS) was present in 70.6% of cases.
- Elevated serum anti-PLA2R antibodies (74.9% positive), BMI, lipids, IgA, and IgE were observed, with decreased IgG.
- Advanced pathological stages correlated with gender, creatinine, and IgE levels.
Conclusions:
- Male and elderly MN patients tend to exhibit more rapid disease progression.
- Advanced pathological stages and positive anti-PLA2R antibody status are potential indicators of MN disease activity.
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