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Updated: Jan 1, 2026

Dynamic Light Scattering Analysis for the Determination of the Particle Size of Iron-Carbohydrate Complexes
Published on: July 7, 2023
An analytical method for Fe(II) and Fe(III) determination in pharmaceutical grade iron sucrose complex and sodium
Daniele Merli1, Antonella Profumo1, Carlo Dossi2
1Dipartimento di Chimica, Università degli Studi di Pavia, Via Taramelli 12/14/16, 27100 Pavia Italy.
Abstract:
A robust voltammetric method has been developed and validated for the determination of Fe(II) and Fe(III) in pharmaceutical iron polysaccharidic complexes. Undesirable low molecular weight iron complexes, at concentration about 3% in the pharmaceutical formulation, can be easily determined with good accuracy and precision. This methodology can be proposed as a viable, environmentally sustainable substitute for the conventional Normal Pulse Polarographic method in US Pharmacopeia, with better analytical figures of merit, and reduced Hg consumption. A deeper insight in Fe(II) and Fe(III) composition can be gained by the combined use of a new potentiometric technique after chemical decomposition of the complex.
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