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Development of a "leak-proof," knitted Dacron vascular prosthesis
Journal of Vascular Surgery
|June 1, 1986
Summary
Collagen impregnation makes knitted Dacron vascular grafts impervious to blood leak without negatively impacting graft healing or surface thrombogenicity. This technique offers a promising advancement for surgical prostheses.
Area of Science:
- Biomaterials Science
- Vascular Surgery
- Regenerative Medicine
Background:
- Knitted Dacron prostheses are widely used in vascular surgery but can suffer from interstitial blood leakage.
- Collagen impregnation is a novel technique to enhance the impermeability of these grafts.
Purpose of the Study:
- To evaluate the effect of collagen impregnation on the surface thrombogenicity and healing of knitted Dacron vascular grafts.
- To determine if collagen impregnation has any deleterious effects on graft performance.
Main Methods:
- Infrarenal aortas of 30 mongrel dogs were replaced with either collagen-impregnated or control Dacron grafts.
- Grafts were harvested at 3, 6, and 9 months for histological and ultrastructural analysis.
- In vivo surface thrombogenicity was assessed in separate experiments.
Main Results:
- Collagen-impregnated grafts demonstrated complete impermeability to blood leak, unlike control grafts.
- Histological and ultrastructural analyses showed identical healing responses between collagen-impregnated and control grafts.
- Collagen-impregnated grafts exhibited improved initial capsule adherence and reduced surface thrombogenicity.
Conclusions:
- Collagen impregnation effectively prevents blood leakage in knitted Dacron prostheses.
- This technique does not adversely affect graft healing or thrombogenicity over the observed period.
- Collagen-impregnated Dacron grafts represent a safe and potentially improved option for vascular reconstruction.