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Pioglitazone: A review of analytical methods
N Satheeshkumar1, S Shantikumar1, R Srinivas2
1Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Hyderabad (NIPER-H), Balanagar, Hyderabad 500037, India.
Journal of Pharmaceutical Analysis
|February 7, 2018
Summary
This review summarizes analytical methods for pioglitazone, an important anti-hyperglycemic drug for type 2 diabetes. It covers techniques for detecting pioglitazone in both pharmaceutical products and biological specimens.
Area of Science:
- Pharmacology
- Analytical Chemistry
Background:
- Pioglitazone is an oral anti-hyperglycemic agent used for type 2 diabetes mellitus.
- It functions by selectively activating the peroxisome proliferator-activated receptor gamma (PPAR-gamma).
- Pioglitazone was a top-selling drug in the U.S. in 2008, highlighting its clinical significance.
Purpose of the Study:
- To review and summarize analytical methods for pioglitazone determination.
- To cover methods applicable to both pharmaceutical formulations and biological samples.
Main Methods:
- The review examines various analytical techniques.
- Methods include electrochemical analysis, spectrophotometry, capillary electrophoresis, and chromatography (HPLC, HPTLC).
- Liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) is also discussed.
Main Results:
- A comprehensive overview of published analytical methods for pioglitazone is presented.
- The methods discussed offer diverse approaches for accurate quantification.
Conclusions:
- Various analytical techniques are available for pioglitazone determination.
- These methods are crucial for quality control and therapeutic monitoring.
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