Related Experiment Video
Updated: Feb 14, 2026

Author Spotlight: Discovering New Biopesticides from Bioactive Soil Microbe-Derived Natural Products
Published on: July 26, 2024
Bioautography and its scope in the field of natural product chemistry
Saikat Dewanjee1, Moumita Gangopadhyay2, Niloy Bhattacharya1
1Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, 188 Raja S C Mullick Road, Kolkata 700032, India.
Abstract:
Medicinal plants, vegetables and fruits are the sources of huge number of bioactive lead/scaffolds with therapeutic and nutraceutical importance. Bioautography is a means of target-directed isolation of active molecules on chromatogram. Organic solvents employed in chromatographic separation process can be completely removed before biological detection because these solvents cause inactivation of enzymes and/or death of living organisms. They offer a rapid and easy identification of bioactive lead/scaffolds in complex matrices of plant extracts. Bioautography is a technique to isolate hit(s)/lead(s) by employing a suitable chromatographic process followed by a biological detection system. This review critically describes the methodologies to identify antimicrobial, antioxidant, enzyme inhibitor lead/scaffolds by employing bioautography. A significant number of examples have been incorporated to authenticate the methodologies.
Related Concept Videos
The Scope of Physics
Chemistry of Carbohydrates
Chemistry of Carbohydrates
What is Natural Selection?
Nature and Nurture
What is Organic Chemistry?

