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Updated: Feb 14, 2026
07:17
An Orthotopic Resectional Mouse Model of Pancreatic Cancer
Published on: September 24, 2020
12.6K
Pancreatic cancer: Current status and Challenges
Amanda R Muñoz1, Divya Chakravarthy1,2,3,4,5,6, Jingjing Gong1,2,3,4,5,6
1Department of Urology, The University of Texas Health Science Center, San Antonio, TX.
Current Pharmacology Reports
|February 7, 2018
Summary
Pancreatic cancer (PanCA) survival rates remain low due to complex signaling pathways and tumor microenvironment interactions. This review explores etiological factors, therapeutic resistance, and natural product-based strategies for improved PanCA management.
Area of Science:
- Oncology
- Cancer Biology
- Pathology
Background:
- Pancreatic cancer (PanCA) exhibits dismal 5-year survival rates, with incidence mirroring mortality.
- Dysregulated signaling pathways are implicated in PanCA development, progression, and therapeutic resistance.
Purpose of the Study:
- To review current knowledge on PanCA etiology, including infectious agents.
- To examine factors contributing to therapeutic resistance in PanCA.
- To summarize existing and potential therapeutic strategies for PanCA management.
Main Methods:
- Literature review of etiological factors in pancreatic cancer.
- Analysis of tumor microenvironment interactions, including desmoplasia.
- Evaluation of therapeutic resistance mechanisms and natural product-based interventions.
Main Results:
- Pancreatic cancer is characterized by desmoplasia, involving stromal fibroblast proliferation and collagen deposition.
- Pancreatic stellate cells (PSCs) are key contributors to PanCA desmoplasia.
- Complex interactions between PSCs, cancer cells, endothelial cells, and myeloid-derived suppressor cells drive pancreatic carcinogenesis.
Conclusions:
- Current therapeutic approaches for PanCA have limitations.
- Natural products and botanicals show promise as adjuvant/neoadjuvant therapies for effective PanCA management.
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