Metabolic Disorders in Chronic Lung Diseases
Ourania Papaioannou1, Theodoros Karampitsakos2, Ilianna Barbayianni3
1First Academic Department of Pneumonology, Hospital for Diseases of the Chest "Sotiria", Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Frontiers in Medicine
|February 7, 2018
Summary
Metabolic disorders like diabetes significantly impact chronic lung diseases, affecting patient quality of life and outcomes. Understanding these links and exploring metabolites offers new therapeutic targets for better disease management.
Area of Science:
- Pulmonary Medicine
- Metabolic Disorders
- Biomarkers
Background:
- Chronic lung diseases (CLDs) are increasing in incidence and complexity.
- CLDs impose a significant medical and financial burden.
- A multidisciplinary, personalized approach, including assessment of metabolic comorbidities, is crucial.
Purpose of the Study:
- To review the prevalence of metabolic comorbidities in CLDs.
- To highlight the impact of these comorbidities on disease progression and mortality.
- To explore mechanistic links and the role of metabolites as therapeutic targets.
Main Methods:
- Literature review of current research on metabolic comorbidities in CLDs.
- Analysis of studies investigating the impact of conditions like diabetes mellitus, dyslipidemia, osteoporosis, vitamin D deficiency, and thyroid dysfunction.
- Examination of metabolomics studies for novel pathogenetic pathways and therapeutic targets.
Main Results:
- Metabolic comorbidities significantly affect symptoms, quality of life, management, and mortality in CLDs.
- Identified mechanistic links between metabolic dysfunctions and chronic lung disease progression.
- Metabolomics studies reveal novel insights into disease modification and potential therapeutic strategies.
Conclusions:
- Metabolic comorbidities are prevalent and impactful in chronic lung diseases.
- Targeting metabolic pathways and utilizing metabolite profiles presents a promising future for managing CLDs.
- Further research into metabolomics can identify new disease modifiers and therapeutic targets.
More Related Videos
Related Concept Videos
01:17Chronic Bowel Disorders: Introduction
816
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
816
01:23Skin Diseases and Disorders
5.6K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.6K
01:24Chronic Obstructive Pulmonary Disease
2.6K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.6K
01:25Chronic Kidney Disease I: Introduction
780
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
780
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
3.9K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.9K
01:29Chronic Obstructive Pulmonary Disease-V: Management
3.3K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
3.3K