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Nuclear Fusion02:45

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The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
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The z-transform is a powerful mathematical tool used in the analysis of discrete-time signals and systems. It is a crucial tool in the analysis of discrete-time systems, but its convergence is limited to specific values of the complex variable z. This range of values, known as the Region of Convergence (ROC), is fundamental in determining the behavior and stability of a system or signal. The ROC defines the region in the complex plane where the z-transform converges, which can take various...
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Convergence of Fourier Series01:21

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The Fourier series is a powerful mathematical tool for representing periodic signals as an infinite sum of complex exponentials. In practice, this infinite series is truncated to a finite number of terms, yielding a partial sum. This truncation makes the approximation of the signal feasible but introduces certain challenges, particularly near discontinuities, known as the Gibbs phenomenon.
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Related Experiment Video

Updated: Feb 14, 2026

mirMachine: A One-Stop Shop for Plant miRNA Annotation
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miRNA-convergent gene fusions.

Carlos Rovira1

  • 1Department of Clinical Sciences Lund, Division of Oncology and Pathology and BioCARE, Strategic Cancer Research Program, Lund University, Lund, Sweden.

Molecular & Cellular Oncology
|February 7, 2018
PubMed
Summary

Intron-encoded microRNA genes (miRNA) frequently partner with fusion genes in cancer genomes. This discovery introduces a new category of genomic rearrangements termed "miRNA-convergent fusions".

Area of Science:

  • Genomics
  • Molecular Biology
  • Cancer Research

Background:

  • Fusion genes are common in cancer.
  • MicroRNA genes (miRNA) play critical roles in gene regulation.
  • The role of intronic miRNA genes in cancer-associated genomic rearrangements is largely unexplored.

Purpose of the Study:

  • To investigate the association between intron-encoded microRNA genes and fusion genes in cancer.
  • To identify and characterize a novel class of genomic rearrangements involving miRNA genes.

Main Methods:

  • Bioinformatic analysis of cancer genome data.
  • Identification and classification of fusion genes.
  • Analysis of microRNA gene locations and expression patterns.
Keywords:
cancergene fusionsgenome aberrationsmicroRNA

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Main Results:

  • Intron-encoded microRNA genes are frequent partners of fusion genes.
  • A new class of fusion events, termed "miRNA-convergent fusions", has been identified.
  • These fusions involve functional aspects of miRNA genes rather than just structural alterations.

Conclusions:

  • Genomic rearrangements involving intron-encoded miRNA genes are prevalent in cancer.
  • The identification of miRNA-convergent fusions provides new insights into cancer development and progression.
  • This finding opens new avenues for understanding the functional impact of non-coding RNAs in oncogenesis.