Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Screens02:46

Genetic Screens

5.8K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.8K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

25.0K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
25.0K
Correlation and Causation01:27

Correlation and Causation

43.0K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
43.0K
Photosystem I01:27

Photosystem I

70.2K
Although structurally similar to photosystem II (PSII), photosystem I (PSI) is has a different electron supplier and electron acceptor.
Both these photosystems work in concert. An excited electron from PSII is relayed to PSI via an electron transport chain in the thylakoid membrane of the chloroplast, which is comprised of the carrier molecule plastoquinone, the dual-protein cytochrome complex, and plastocyanin. As electrons move between PSII and PSI, they lose energy and must be re-energized...
70.2K
Photosystem II01:22

Photosystem II

78.9K
The multi-protein complex photosystem II (PS II) harvests photons and transfers their energy through its bound pigments to its reaction center, and ultimately to photosystem I (PSI) through the electron transport chain. The pigments responsible for caputirng the light energy in photosystems include chlorophyll a, chlorophyll b, and carotenoids.
The pigment molecules are arranged across  two photosystem domains — the antenna complex and the reaction center. The main aim of the pigment...
78.9K
Base Excision Repair01:54

Base Excision Repair

26.5K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
26.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of Liver Fibrosis Change After DAA-induced Cure of Hepatitis C in Participants With and Without HIV: ACTG A5320 Viral Hepatitis C Infection Long-term Cohort Study (VHICS).

Open forum infectious diseases·2026
Same author

Patients who underwent TIPS face increases in hernia incarceration rates compared to patients managed with paracentesis: An analysis of prevalence and risk factors.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2025
Same author

Diagnostic Utility of Pre-Genomic Hepatitis B RNA in the Evaluation of HBV/HIV Coinfection.

Pathogens & immunity·2024
Same author

Design and analysis considerations for early phase clinical trials in hepatitis B (HBV) cure research: the ACTG A5394 study in persons with both HIV and HBV.

Journal of virus eradication·2023
Same author

Chronic Hepatitis B Finite Treatment: Similar and Different Concerns With New Drug Classes.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2023
Same author

Comparison of Antiretroviral Therapies in Pregnant Women Living With Human Immunodeficiency Virus and Hepatitis B Virus: A Randomized Controlled Trial.

Obstetrics and gynecology·2023
Same journal

Financial burden among liver transplant candidates is associated with financial distress and work impairment: A U.S. multicenter study.

Hepatology communications·2026
Same journal

Neoadjuvant therapy in primary liver cancer: From the missing piece to a new paradigm.

Hepatology communications·2026
Same journal

Hepatology e-consult responses generated by artificial intelligence demonstrate accuracy but require human oversight.

Hepatology communications·2026
Same journal

The Transitional Liver Clinic: Study protocol for a stepped-wedge cluster randomized trial.

Hepatology communications·2026
Same journal

Methylation plus alpha-fetoprotein blood test for early detection of HCC in at-risk populations.

Hepatology communications·2026
Same journal

The PERK-GADD45A axis is a key driver of hepatic stellate cell activation.

Hepatology communications·2026
See all related articles

Related Experiment Video

Updated: Feb 14, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
05:06

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

Published on: October 24, 2015

12.9K

Screening for hepatocellular carcinoma: What is missing?

Neil J Mehta1, Aygul Dogan Celik1,2, Marion G Peters1

  • 1Department of Medicine University of California San Francisco CA.

Hepatology Communications
|February 7, 2018
PubMed
Summary
This summary is machine-generated.

Physicians often fail to screen patients for hepatocellular carcinoma (HCC) according to established guidelines. Improving HCC screening practices is crucial for better patient outcomes and survival rates.

More Related Videos

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients
05:31

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Published on: September 20, 2020

6.2K
Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice
10:35

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

Published on: September 25, 2013

37.2K

Related Experiment Videos

Last Updated: Feb 14, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
05:06

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

Published on: October 24, 2015

12.9K
Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients
05:31

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Published on: September 20, 2020

6.2K
Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice
10:35

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

Published on: September 25, 2013

37.2K

Area of Science:

  • Hepatology
  • Oncology
  • Viral Hepatitis Management

Background:

  • Established guidelines exist for hepatocellular carcinoma (HCC) screening and management by major liver societies.
  • Current practices reveal significant challenges and deficiencies in the actual implementation of HCC screening.
  • Hepatitis C treatment advancements, while beneficial, present ongoing risks for HCC development, even post-cure.

Purpose of the Study:

  • To critically evaluate the current diagnostic and screening practices for hepatocellular carcinoma (HCC).
  • To highlight the discrepancies between recommended HCC screening guidelines and clinical reality.
  • To emphasize the importance of timely and accurate screening for improving patient survival.

Main Methods:

  • Review of existing literature and clinical guidelines on HCC diagnosis and screening.
  • Analysis of current screening practices and their effectiveness.
  • Discussion of challenges in HCC screening adherence.

Main Results:

  • Despite guidelines, the practical application of HCC screening is suboptimal.
  • Accurate diagnosis of cirrhosis and timely screening are critical for improved survival post-HCC diagnosis.
  • Direct-acting antiviral therapy for hepatitis C may be associated with an increased risk of HCC in some cases.

Conclusions:

  • There is a pressing need to improve physician adherence to current HCC screening recommendations.
  • Enhancing the quality and timeliness of HCC screening is paramount for improving patient outcomes.
  • Further research is needed to understand the evolving risks of HCC in the context of hepatitis C treatment.