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Implantation of Engineered Tissue in the Rat Heart
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Liver tissue engineering: From implantable tissue to whole organ engineering
Giuseppe Mazza1, Walid Al-Akkad1, Krista Rombouts1
1University College London, Division of Medicine, Institute for Liver and Digestive Health Royal Free Hospital London United Kingdom.
Hepatology Communications
|February 7, 2018
Summary
Liver tissue engineering aims to regenerate liver function using cells within 3D structures. Advances in biomaterials and bioprinting show promise for treating liver disorders.
Area of Science:
- Biotechnology
- Regenerative Medicine
- Tissue Engineering
Background:
- Liver disorders necessitate innovative treatments.
- Current limitations in liver transplantation and artificial liver devices.
- The growing field of liver tissue engineering offers potential solutions.
Purpose of the Study:
- To review the current state and future directions of liver tissue engineering.
- To explore methodologies for creating functional liver tissue.
- To highlight advancements in cell sourcing, biomaterials, and biofabrication.
Main Methods:
- Utilizing adult hepatocytes or stem cell-derived hepatocyte-like cells.
- Embedding cells in 3D scaffolds (e.g., alginate, gelatin) or pre-arranged biomaterial structures.
- Employing three-dimensional bioprinting with bio-inks for precise cell deposition.
Main Results:
- Engineered cell microenvironments increasingly mimic native liver extracellular matrix.
- Preclinical studies demonstrate promising outcomes for liver tissue regeneration.
- Advancements in bioreactors, ex vivo perfusion, and cell expansion systems are accelerating progress.
Conclusions:
- Liver tissue engineering holds significant potential for treating liver diseases.
- Continued research in cell microenvironment engineering is crucial.
- Technological advancements are paving the way for clinical applications in liver repair and replacement.
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