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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
Medulloblastoma in association with sacral agenesis; a case report
Zahra Ebrahim Soltani1, Zohreh Habibi2, Farideh Nejat1
1Department of Neurosurgery, Children's Hospital Medical Center, Tehran University of Medical Sciences, No 62, Qarib St., Keshavarz Blvd, Tehran, 1419733151, Iran.
Abstract:
Medulloblastoma is a congenital brain tumor which can be associated with different congenital anomalies. However, coincidence of cerebellar medulloblastoma with sacral agenesis has not been reported so far. A variety of genetic and/or environmental predisposing factors have been proposed for both diseases. Herein, an unprecedented coincidence of these two conditions is presented. A neonate was born with lumbosacral agenesis, paraplegia, and atrophic legs, and he developed medulloblastoma with three ventricular hydrocephalus 3 years later. Different aspects regarding the embryology and etiology of both ailments are discussed, assuming the possibility that the same genetic and/or environmental risk factors may have played a part in both conditions.
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