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Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

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Related Experiment Video

Updated: Feb 14, 2026

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

Migraine and the Hippocampus.

Hung-Yu Liu^1,2, Kun-Hsien Chou^3,4, Wei-Ta Chen^5,6,7

¹Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, No. 201, Sec. 2 Shih-Pai Rd, Taipei, Taiwan. christie393@yahoo.com.tw.

Current Pain and Headache Reports

|February 7, 2018

Summary

Migraine affects hippocampal volume and activity, with changes linked to headache frequency and genetic factors. Further research is needed to understand the hippocampus

Keywords:

Connectivity Hippocampus MRI Migraine Stress Volume

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Last Updated: Feb 14, 2026

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Published on: August 11, 2021

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Published on: June 2, 2014

Area of Science:

Neuroscience
Neurology
Pain Research

Background:

The hippocampus plays a role in pain processing, attention, anxiety, and stress response.
Understanding hippocampal involvement is crucial for migraine research.

Purpose of the Study:

To review current knowledge on hippocampal volume, activity, and connectivity in migraine patients.
To explore factors influencing these hippocampal changes.

Main Methods:

Review of longitudinal and cross-sectional studies on hippocampal morphology and function in migraine.
Analysis of studies investigating functional and structural connectivity.

Main Results:

Migraine patients show altered hippocampal volume (decreased longitudinally, variable cross-sectionally) and activity.
Hippocampal connectivity is modified, correlating with headache frequency, genetics, and psychological factors.
Genetic variants (e.g., COMT Val homozygous) influence hippocampal size and connectivity.

Conclusions:

The hippocampus is dynamically involved in migraine pathophysiology.
Headache frequency, genetic predispositions, and psychological states significantly impact hippocampal structure and function in migraine.
Precise participant selection and genetic control are essential for future studies.