Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Trial and Error and Algorithm01:12

Trial and Error and Algorithm

435
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
435
Clinical Trials: Overview01:11

Clinical Trials: Overview

5.1K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.1K
Clinical Trials01:16

Clinical Trials

10.9K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.9K
Overview of the Cardiovascular System01:14

Overview of the Cardiovascular System

12.3K
The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
12.3K
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

4.2K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
4.2K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

4.6K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estimating optimal dynamic treatment regimes with Gaussian process emulation.

Biometrics·2026
Same author

A Bayesian non-stationary heteroskedastic time series model for multivariate critical care data.

Statistics in medicine·2024
Same author

Identifying Differential Methylation in Cancer Epigenetics via a Bayesian Functional Regression Model.

Biomolecules·2024
Same author

The time-dependent Poisson-gamma model in practice: Recruitment forecasting in HIV trials.

Contemporary clinical trials·2024
Same author

The survival function NPMLE for combined right-censored and length-biased right-censored failure time data: properties and applications.

The international journal of biostatistics·2024
Same author

The evolution of SARS-CoV-2 seroprevalence in Canada: a time-series study, 2020-2023.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2023

Related Experiment Video

Updated: Feb 14, 2026

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.3K

Bayesian adaptive trials for rare cardiovascular conditions.

Azadeh Shohoudi1, David A Stephens2, Paul Khairy1,3

  • 1Montreal Health Innovations Coordinating Center (MHICC), Montreal, Canada.

Future Cardiology
|February 7, 2018
PubMed
Summary

Bayesian adaptive trials offer efficient and flexible cardiovascular study designs, especially for small populations. These methods reduce risks and costs by integrating prior knowledge with new data for adaptive decision-making.

Keywords:
Bayesian clinical trialadaptive trialcardiovascular diseaserandomized clinical trial

More Related Videos

Author Spotlight: Advancing Metabolomics Analysis of Rare Hematopoietic Stem Cells
08:28

Author Spotlight: Advancing Metabolomics Analysis of Rare Hematopoietic Stem Cells

Published on: February 23, 2024

2.6K
Identifying Amino Acid Overproducers Using Rare-Codon-Rich Markers
10:41

Identifying Amino Acid Overproducers Using Rare-Codon-Rich Markers

Published on: June 24, 2019

8.8K

Related Experiment Videos

Last Updated: Feb 14, 2026

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.3K
Author Spotlight: Advancing Metabolomics Analysis of Rare Hematopoietic Stem Cells
08:28

Author Spotlight: Advancing Metabolomics Analysis of Rare Hematopoietic Stem Cells

Published on: February 23, 2024

2.6K
Identifying Amino Acid Overproducers Using Rare-Codon-Rich Markers
10:41

Identifying Amino Acid Overproducers Using Rare-Codon-Rich Markers

Published on: June 24, 2019

8.8K

Area of Science:

  • Biostatistics
  • Clinical Trial Design
  • Cardiovascular Research

Background:

  • Rising cardiovascular trial costs hinder medical innovation.
  • Need for efficient and flexible study designs is critical.
  • Bayesian methods are suitable for small populations and adaptive trials.

Purpose of the Study:

  • To explore the utility of Bayesian adaptive trials in cardiovascular research.
  • To highlight the advantages of adaptive designs in managing trial efficiency and costs.
  • To present Bayesian adaptive trials as a solution for modern medical innovation.

Main Methods:

  • Utilizing the Bayesian paradigm for statistical modeling.
  • Implementing adaptive design features: modified randomization, sample size adjustments, continuous surveillance.
  • Combining prior information with accumulating trial data.

Main Results:

  • Bayesian adaptive trials enhance efficiency and flexibility.
  • Adaptive features allow for informed decisions on study arms and early termination.
  • Potential for significant cost savings and risk minimization.

Conclusions:

  • Bayesian adaptive trials represent a powerful framework for cardiovascular research.
  • These designs facilitate the incorporation of new knowledge during the trial.
  • The approach offers intuitive interpretability and facilitates complex computations with available tools.