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Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair
06:37

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

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Current status of stem cells in cardiac repair

Robert J Henning1

  • 1Department of Environmental & Occupational Health, College of Public Health, University of South Florida & the James A Haley Hospital, Tampa, FL 33612-3805, USA.

Future Cardiology
|February 7, 2018
PubMed

Insights

Acute myocardial infarction (AMI) and congestive heart failure (CHF) affect millions. This review explores stem cell therapies, including embryonic, cardiac, bone marrow, and mesenchymal stem cells, as innovative treatments for these prevalent heart conditions.

Area of Science:

  • Cardiovascular Medicine
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • High lifetime incidence of acute myocardial infarction (AMI) affects men and women over 40.
  • Increased survival post-AMI leads to a rising prevalence of congestive heart failure (CHF).
  • Millions in the USA suffer from ischemic cardiomyopathies and CHF, necessitating novel therapeutic approaches.

Purpose of the Study:

  • To review current stem cell investigations for treating AMI and CHF.
  • To examine the therapeutic potential of various stem cell types and their derivatives.

Main Methods:

  • Review of current scientific literature on stem cell applications in cardiology.
  • Analysis of studies involving human embryonic stem cells, cardiac stem/progenitor cells, bone marrow-derived mononuclear cells, and mesenchymal stem cells.
  • Inclusion of research on stem cell paracrine factors and exosomes.

Main Results:

  • Ongoing investigations explore diverse stem cell sources for cardiac repair.
  • Stem cell paracrine factors and exosomes are emerging as potential therapeutic agents.

Conclusions:

  • Stem cell-based therapies show promise for treating acute myocardial infarction and congestive heart failure.
  • Further research into stem cell paracrine factors and exosomes is warranted for novel treatment strategies.

Keywords:
Pim-1acute myocardial infarctionanti-inflammatory cytokinesc-kit cardiac stem/progenitor cellscardiomyopathycardiopoietic mesenchymal stem cellscardiosphere-derived cellscongestive heart failureembryonic stem cellsexosomesgrowth factorsmesenchymal stem cellsparacrine factors

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