Related Experiment Video
Updated: Feb 14, 2026

Selection of Transporter-Targeted Inhibitory Nanobodies by Solid-Supported-Membrane SSM-Based Electrophysiology
Published on: May 3, 2021
Dosing strategy based on prevailing aminoglycoside minimum inhibitory concentration in India: Evidence and issues
Balaji Veeraraghavan1, Agila Kumari Pragasam1, Abi Manesh2
1Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
Abstract:
Aminoglycosides are important agents used for treating drug-resistant infections. The current dosing regimen of aminoglycosides does not achieve sufficient serum level concentration for the infected bacterial pathogen interpreted as susceptible based on laboratory testing. Minimum inhibitory concentration was determined for nearly 2000 isolates of Enterobacteriaceae and Pseudomonas aeruginosa by broth microdilution method. Results were interpreted based on CLSI and EUCAST interpretative criteria and the inconsistencies in the susceptibility profile were noted. This study provides insights into the inconsistencies existing in the laboratory interpretation and the corresponding clinical success rates. This urges the need for revising clinical breakpoints for amikacin, to resolve under dosing leading to clinical failure.
More Related Videos
Related Concept Videos
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
The Evidence for Evolution
Estimation of k and VD of Aminoglycosides
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Ethical Issues
Ethical Concerns in Healthcare:
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

