Related Experiment Video
Updated: Feb 14, 2026

Three-Dimensional Reconstruction of Orbital Fractures
Published on: May 16, 2025
Sirolimus-induced regression of a large orbital lymphangioma
Wolf A Lagrèze1,2, Lutz Joachimsen1,2, Nikolai Gross1,2
1a Eye Center, Medical Center and Medical Faculty , University of Freiburg , Freiburg , Germany.
Abstract:
Microcystic lymphatic malformations are difficult to treat surgically, especially when located in the orbital apex. Recently, pharmacologic inhibition of the mTOR pathway by sirolimus was reported as a safe and efficacious treatment option for lymphatic malformations (also known as lymphangiomas). We report the case of a young male patient in which a unilateral, retrobulbar lymphatic malformation regressed to a large extent under treatment with 1 mg sirolimus given orally twice a day over a period of six months.
Related Concept Videos
Regression Toward the Mean
Atomic Orbitals
Molecular Orbital Theory I
Molecular Orbital Theory II
Hybridization of Atomic Orbitals II
Hybridization of Atomic Orbitals I

