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Published on: August 11, 2013
Adult hypophosphatasia
1INSERM U1153; Département de rhumatologie, hôpital Cochin, assistance publique-hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
Abstract:
In adults, hypophosphatasia (HPP) may be revealed by fractures, mainly metatarsal and femoral, and by crystal-related joint diseases. Low alkaline phosphatase levels are often overlooked. There is no established treatment for adults but the diagnosis is important to prevent the use of therapies that promote bone resorption in this context of bone fragility.
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