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Recent Advances in Nanoparticle-Based Cancer Drug and Gene Delivery

Narsireddy Amreddy1, Anish Babu1, Ranganayaki Muralidharan1

  • 1The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.

Advances in Cancer Research
|February 7, 2018
PubMed

Insights

Nanotechnology offers safe and effective nanoparticle drug delivery systems for cancer therapy, overcoming issues like toxicity and poor bioavailability of traditional anticancer agents. This review explores nanoparticle strategies for various cancer therapeutics.

Area of Science:

  • Oncology
  • Materials Science
  • Nanotechnology

Background:

  • Effective anticancer agent delivery faces challenges including toxicity to normal cells, poor bioavailability, and instability in vivo.
  • Nanotechnology presents a promising solution with nanoparticles as safe and efficient drug delivery systems.
  • Various anticancer agents, such as chemotherapeutics and nucleic acid-based therapeutics, require tailored nanoparticle designs.

Purpose of the Study:

  • To review nanoparticle-based drug delivery strategies for diverse anticancer agents.
  • To highlight recent advancements in nanoparticle drug delivery for cancer therapy.
  • To discuss how the properties of anticancer agents influence nanoparticle carrier development.

Main Methods:

  • Review of scientific literature on nanoparticle drug delivery systems in cancer therapy.
  • Analysis of physicochemical and functional properties of nanoparticles for different therapeutic agents.
  • Inclusion of examples from published research and the authors' own work.

Main Results:

  • Nanoparticles can be engineered to improve the delivery, efficacy, and safety of various anticancer agents.
  • The design of nanoparticle carriers is critically dependent on the specific characteristics of the anticancer agent being delivered.
  • Recent advancements show significant progress in tailoring nanoparticles for targeted cancer treatment.

Conclusions:

  • Nanoparticle-based drug delivery is a key strategy for overcoming limitations in current cancer therapy.
  • Tailored nanoparticle design is essential for optimizing the delivery of different classes of anticancer agents.
  • Continued research in nanotechnology holds significant promise for advancing cancer treatment efficacy and safety.
Keywords:
ChemotherapeuticsDrug deliveryExosomesGene therapyNanoparticleTumor targeting

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