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The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
Published on: June 30, 2014
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Cognition in multiple sclerosis: Between cognitive reserve and brain volume.
G Fenu1, L Lorefice1, M Arru1
1Multiple Sclerosis Center, Binaghi Hospital, ATS Sardegna, Department of Medical Sciences and Public Health, University of Cagliari, Italy.
Journal of the Neurological Sciences
|February 7, 2018
Summary
Cognitive impairment in multiple sclerosis (MS) correlates with reduced brain volume, especially gray matter. Cognitive reserve plays a key role in mitigating these cognitive changes in MS patients.
Area of Science:
- Neuroscience
- Radiology
- Neurology
Background:
- Cognitive impairment (CI) is a known issue in multiple sclerosis (MS).
- Radiologic markers and cognitive reserve (CR) have been linked to CI in MS.
- Understanding these relationships is crucial for managing MS patients.
Purpose of the Study:
- To investigate the correlation between cognitive impairment and brain volume (BV) in MS patients.
- To explore the potential mitigating role of cognitive reserve (CR) in this relationship.
Main Methods:
- 195 relapsing MS patients underwent neuropsychological testing (BICAMS).
- Brain volume (BV) was assessed using SIENAX, measuring normalized brain, white matter, gray matter, and cortical gray matter volumes.
- Cognitive reserve was quantified using a validated tool.
Main Results:
- Cognitive function, measured by the Symbol Digit Modality Test (SDMT), correlated with normalized brain volume (NBV), normalized gray matter volume (NGV), normalized cortical gray matter volume (CGV), and cognitive reserve index (CRI).
- Linear regression indicated that CR scores and NGV were significant predictors of SDMT performance.
- Patients with cognitive impairment showed significantly lower NBV, NGV, CGV, and CR scores compared to those with preserved cognition.
Conclusions:
- Brain volume, particularly gray matter volume, is significantly correlated with cognitive function in MS.
- Cognitive reserve is a crucial factor that influences cognitive function in the complex interplay of factors affecting MS patients.
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