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Related Experiment Video

Updated: Feb 14, 2026

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering

Published on: January 24, 2025

Syphilis in Children.

Sarah Heston¹, Sandra Arnold¹

¹Department of Pediatrics, University of Tennessee Health Science Center, Le Bonheur Children's Hospital, Faculty Office Building, 49 North Dunlap Street, Room 293, Memphis, TN 38105, USA.

Infectious Disease Clinics of North America

|February 7, 2018

Summary

This summary is machine-generated.

Syphilis, a Treponema pallidum infection, spreads sexually and from mother to child. Early diagnosis and treatment are crucial for preventing severe outcomes in children and adults, especially pregnant women and adolescents.

Keywords:

Antibodies Congenital infection Penicillin G Syphilis

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Last Updated: Feb 14, 2026

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Area of Science:

Infectious Diseases
Pediatrics
Public Health

Background:

Syphilis, caused by Treponema pallidum, is a significant global health concern.
It can be transmitted sexually and vertically from mother to neonate.
Untreated syphilis leads to severe, progressive illness, including potential death or disability.

Purpose of the Study:

To review the current epidemiology of syphilis.
To outline clinical manifestations, diagnosis, and management of syphilis in pediatric practice.
To focus on congenital syphilis and acquired syphilis in adolescents and pregnant women.

Main Methods:

Review of current literature on syphilis epidemiology.
Synthesis of diagnostic criteria for congenital and acquired syphilis.
Examination of management strategies relevant to pediatric populations.

Main Results:

Syphilis diagnosis relies on a two-stage serologic testing approach.
Congenital syphilis diagnosis involves maternal history, antibody titer comparison, and neonatal clinical assessment.
The review synthesizes current knowledge on syphilis impacting pediatric care.

Conclusions:

Effective syphilis management requires accurate diagnosis and timely treatment.
Pediatricians and healthcare providers must be aware of syphilis manifestations and diagnostic nuances.
Addressing syphilis in pregnant women and adolescents is critical for preventing congenital transmission and secondary infections.