Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

503
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
503
Renal Corpuscle01:20

Renal Corpuscle

7.6K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
7.6K
Renal Clearance01:23

Renal Clearance

2.8K
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
2.8K
Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

Renal Drug Clearance: Comparison Between Renal Excretion Methods

643
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
643
Drug Elimination: Non-Renal Routes01:23

Drug Elimination: Non-Renal Routes

3.4K
The liver plays a pivotal role in eliminating drugs and their metabolites, primarily through a process known as biliary excretion. This process involves the hepatocytes, the primary cells in the liver that generate bile. A range of transporters actively expels polar drugs or hydrophilic drug metabolites into the bile, which transports the drugs and metabolites into the small intestine. From here, they are eventually expelled from the body through feces. In some instances, the original drug or a...
3.4K
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

3.7K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Outcome of ABO-incompatible living-donor kidney transplants : A plea for crossover living-donor kidney transplantation].

Urologie (Heidelberg, Germany)·2024
Same author

[Report on the 29th annual meeting of the kidney transplantation working group of the German Society of Urology in Marburg 2023].

Urologie (Heidelberg, Germany)·2024
Same author

Results of an international, randomized trial comparing glucose metabolism disorders and outcome with cyclosporine versus tacrolimus. Am J Transplant 7 1506-1514, 2007.

Clinical journal of the American Society of Nephrology : CJASN·2023
Same author

[Management of critically ill nontrauma patients in a nonuniversity emergency department].

Notfall & rettungsmedizin·2022
Same author

[Auricular chondritis as first symptom of ANCA-associated vasculitis].

Zeitschrift fur Rheumatologie·2020
Same author

[Organ donation in Germany under the new legislation].

Der Urologe. Ausg. A·2020

Related Experiment Video

Updated: Feb 14, 2026

Murine Renal Transplantation Procedure
18:48

Murine Renal Transplantation Procedure

Published on: July 10, 2009

30.7K

Late Steroid Withdrawal Following AB0-Incompatible Renal Transplantation.

F Bachmann1, N Lachmann2, K Budde1

  • 1Medizinische Klinik mit Schwerpunkt Nephrologie und Internistische Intensivmedizin, Charité-Universitätsmedizin Berlin, Germany.

Transplantation Proceedings
|February 7, 2018
PubMed
Summary
This summary is machine-generated.

Late steroid withdrawal after ABO-incompatible kidney transplants is feasible but carries a moderate rejection risk. Close monitoring of renal function and HLA antibodies is recommended post-withdrawal.

More Related Videos

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
06:59

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection

Published on: February 2, 2022

4.5K
Direct Drug Delivery to Kidney via the Renal Artery
11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

8.3K

Related Experiment Videos

Last Updated: Feb 14, 2026

Murine Renal Transplantation Procedure
18:48

Murine Renal Transplantation Procedure

Published on: July 10, 2009

30.7K
A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
06:59

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection

Published on: February 2, 2022

4.5K
Direct Drug Delivery to Kidney via the Renal Artery
11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

8.3K

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Immunosuppression Therapy

Background:

  • Evidence on steroid withdrawal post-ABO-incompatible (ABOi) renal transplantation is limited.
  • This study compares outcomes of late steroid withdrawal versus continued steroid treatment.

Purpose of the Study:

  • To evaluate the feasibility and outcomes of late steroid withdrawal in ABOi renal transplant recipients.
  • To compare graft survival, rejection rates, and renal function between steroid withdrawal and maintenance groups.

Main Methods:

  • A retrospective analysis of 11 patients undergoing late steroid withdrawal (group W) at ≥12 months post-transplant.
  • Comparison with 19 patients on maintenance triple immunosuppression including steroids (group M).
  • Minimum follow-up of 24 months post-transplant and 12 months post-withdrawal.

Main Results:

  • Graft survival was 100% in group W versus 84% in group M (P=0.15).
  • One episode of antibody-mediated rejection (ABMR) occurred in group W post-withdrawal; one patient in group M had graft failure due to ABMR.
  • Estimated glomerular filtration rates (eGFR) were similar between groups (54 mL/min/1.73 m² in W vs. 60 mL/min/1.73 m² in M).

Conclusions:

  • Late steroid withdrawal is feasible in ABOi renal transplantation, with a manageable risk of rejection.
  • Close monitoring of renal function and HLA antibodies is crucial during and after steroid withdrawal.
  • The risk of severe infections and graft loss in patients on long-term steroid-based immunosuppression highlights the need to balance immunosuppressive burden.