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Chronic amphetamine treatment affects collicular-dependent behaviour.

Amy C Turner1, Agata Stramek1, Igor Kraev1

  • 1School of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK7 6AA, UK.

Behavioural Brain Research
|February 7, 2018
PubMed
Summary

Chronic amphetamine treatment in rats did not affect visual attention but impaired height-dependent righting reflexes, suggesting effects on the superior colliculus. This research explores amphetamine

Keywords:
Air-rightingAmphetamineDistractibilityOrientingSuperior colliculus

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Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Pharmacology

Background:

  • Distractibility is an attention deficit characterized by an inability to inhibit orientation toward irrelevant stimuli.
  • The superior colliculus is implicated as a neural correlate of distractibility, with its activity linked to attentional deficits.
  • Amphetamine acutely reduces distractibility by suppressing collicular responsiveness, but the effects of chronic amphetamine treatment on the colliculus are unknown.

Purpose of the Study:

  • To investigate the impact of chronic amphetamine treatment on colliculus-dependent behaviors in rats.
  • To assess whether long-term amphetamine administration affects visual orienting and height-dependent modulation of the air-righting reflex.

Main Methods:

  • Healthy hooded Lister rats underwent a twenty-eight day chronic amphetamine treatment regimen.
  • Two colliculus-dependent behaviors were assessed post-treatment: visual stimulus orienting and height-dependent air-righting modulation.
  • Behavioral responses were analyzed to determine the effects of amphetamine on these functions.

Main Results:

  • Chronic amphetamine treatment did not significantly alter visual orienting to novel stimuli, although dose-dependent decreases in orienting to repeated stimuli were observed.
  • Amphetamine treatment significantly impaired the ability to modulate the air-righting reflex based on drop height, a colliculus-dependent function.
  • These findings suggest chronic amphetamine affects specific colliculus-mediated processes.

Conclusions:

  • Chronic amphetamine administration impacts colliculus-dependent functions, specifically the height-modulation of the air-righting reflex.
  • The results align with acute amphetamine's suppression of collicular activity, potentially through mechanisms like increased receptive field size.
  • Further research is needed to elucidate the precise neural mechanisms underlying these behavioral changes induced by chronic amphetamine.