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Updated: Feb 14, 2026

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
Published on: July 10, 2018
Studies on the interaction of NMDA receptor antagonist memantine with cell membranes: A mini-review
Pablo Zambrano1, Mario Suwalsky1, Malgorzata Jemiola-Rzeminska2
1Faculty of Chemical Sciences, University of Concepción, Concepción, Chile.
Abstract:
Memantine is an NMDA receptor antagonist clinically used for the treatment of moderate to severe Alzheimer's disease. Currently, it is the only NMDA receptor antagonist drug marketed against this disease. Despite the large number of publications regarding its clinical and therapeutic use, studies related to its mechanism of action are still inconclusive. Knowledge of drug interactions with cell membranes may lead to the development of novel drugs for neurodegenerative diseases. The present mini-review aims to give an overview of the latest findings regarding the interaction of memantine with cell membranes, specifically with that of the human erythrocyte.
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