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Therapeutic cancer vaccines: From initial findings to prospects

Qian Song1, Cheng-Dong Zhang2, Xiang-Hua Wu1

  • 1Department of Medical Oncology, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, 130 Dong-An Road, Shanghai 200032, China.

Immunology Letters
|February 7, 2018
PubMed

Insights

Personalized cancer vaccines targeting neoantigens show promise for inducing tumor regression. This review explores therapeutic cancer vaccine strategies and their clinical trial developments.

Area of Science:

  • Oncology
  • Immunology
  • Vaccinology

Background:

  • The first therapeutic cancer vaccine approval marked a milestone.
  • Numerous therapeutic cancer vaccines are in clinical trials, showing antitumor immune responses.

Purpose of the Study:

  • To review therapeutic cancer vaccine strategies.
  • To highlight personalized cancer vaccines based on neoantigens.
  • To discuss tumor-specific antigen selection methods.

Main Methods:

  • Review of clinical trial data.
  • Analysis of therapeutic cancer vaccine strategies.
  • Focus on neoantigen-based vaccine development.

Main Results:

  • Personalized cancer vaccines demonstrate potential for tumor regression.
  • Neoantigen-based vaccines are an emerging efficient therapeutic approach.

Conclusions:

  • Therapeutic cancer vaccines are advancing, with personalized neoantigen vaccines showing significant promise.
  • Further clinical trials are crucial for demonstrating efficacy.
Keywords:
Cancer vaccineImmunotherapyNeoantigenTumor antigen

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