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Related Concept Videos

Sampling Methods: Sample Types01:18

Sampling Methods: Sample Types

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Sampling materials are classified into three main types: solid, liquid, and gas.
Solid samples include a variety of substances, such as sediments from water bodies, soil, metals, and biological tissues. Two standard methods for extracting sediments from water bodies are grab sampling and piston coring. Grab sampling involves using a device to collect a discrete sediment sample from the bottom of a water body with minimal disturbance. Grab samples do not always represent the entire area due to...
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Convenience Sampling Method00:55

Convenience Sampling Method

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Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population.
Convenience sampling is a non-random method of sample selection; this method selects individuals that are easily accessible and may result in biased data. For example, a marketing...
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Sampling Methods: Overview01:06

Sampling Methods: Overview

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A sample refers to a smaller subset representative of a larger population. In analytical chemistry, studying or analyzing an entire population is often impractical or impossible. Therefore, samples are used to draw inferences and generalize the whole population. The sampling method selects individuals or items from a population to create a sample. Standard sampling methods include random, judgemental, systematic, stratified, and cluster sampling. 
In analytical chemistry, the choice of...
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Systematic Sampling Method01:17

Systematic Sampling Method

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Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
13.4K
Stratified Sampling Method01:16

Stratified Sampling Method

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Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
To choose a stratified sample, divide the population into groups called strata and then take a...
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Cluster Sampling Method01:20

Cluster Sampling Method

14.9K
Appropriate sampling methods ensure that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
To choose a cluster sample, divide the population into clusters (groups) and then randomly select some of the clusters. All the members from these clusters are in the cluster sample. For example, if you randomly sample four departments from your...
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Related Experiment Video

Updated: Feb 14, 2026

A Simple Double Centrifugation Tube Method to Obtain Platelet-rich Plasma from Equine Blood
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A Simple Double Centrifugation Tube Method to Obtain Platelet-rich Plasma from Equine Blood

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Simple method for removing DOACs from plasma samples.

T Exner1, N Michalopoulos2, J Pearce2

  • 1Haematex Research Pty Ltd, Sydney, Australia.

Thrombosis Research
|February 7, 2018
PubMed
Summary
This summary is machine-generated.

DOAC Stop effectively removes direct oral anti-coagulants (DOACs) from plasma samples. This method minimizes interference with routine coagulation tests, improving diagnostic accuracy for lupus anticoagulants.

Keywords:
APTTApixabanClotting testsDOACDOAC adsorbentDabigatranEdoxabanLupus anticoagulantRivaroxabandRVVT

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Area of Science:

  • Hematology
  • Clinical Chemistry
  • Pharmacology

Background:

  • Direct oral anti-coagulants (DOACs) are widely used anticoagulants.
  • DOACs can interfere with various laboratory coagulation tests, leading to potential misdiagnosis.
  • Accurate interpretation of coagulation assays in patients on DOACs requires methods to mitigate their effects.

Purpose of the Study:

  • To evaluate the efficacy of DOAC Stop, an adsorbent product, for removing DOACs from plasma.
  • To assess the impact of DOAC Stop on standard coagulation assays.
  • To determine the utility of DOAC Stop in improving the accuracy of lupus anticoagulant testing.

Main Methods:

  • DOAC Stop was tested on normal and abnormal plasma samples spiked with various DOACs.
  • Initial testing involved activated partial thromboplastin time (APTT) and a DOAC-sensitive Russells viper venom-based clotting test (DOAC Test).
  • Further analyses included PT/INR, lupus anticoagulants (dRVVT), APC resistance, and other coagulation factors.

Main Results:

  • DOAC Stop successfully removed all tested DOACs (dabigatran, apixaban, rivaroxaban, edoxaban) from plasma.
  • The adsorbent showed minimal impact on the results of routine clotting tests.
  • DOAC Stop reduced false-positive lupus anticoagulant results in dRVVT assays.

Conclusions:

  • DOAC Stop is a simple and effective method for removing DOACs from plasma.
  • This product can aid in identifying DOAC presence using standard clotting tests.
  • DOAC Stop can enhance the reliability of coagulation testing in patients treated with DOACs.