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Updated: Aug 6, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Summary
Topical and oral antifungal agents effectively treat many dermatophyte infections. However, some infections like onychomycosis and T. rubrum sole infections remain resistant, requiring further research into optimal treatment strategies.
Area of Science:
- Dermatology
- Mycology
- Pharmacology
Background:
- Dermatophytosis treatment relies on topical and oral antifungal agents.
- Griseofulvin and ketoconazole are used for widespread or severe fungal infections.
- Clinical resistance to antifungal therapies is observed in specific dermatophyte infections.
Purpose of the Study:
- To review the efficacy of current antifungal therapies for dermatophytosis.
- To identify dermatophyte infections that are clinically resistant to treatment.
- To highlight areas for future research in antifungal drug development and delivery.
Main Methods:
- Review of existing literature on topical and oral antifungal agents for dermatophytosis.
- Analysis of clinical resistance patterns in various dermatophyte infections.
- Identification of challenges in drug penetration for difficult-to-treat sites.
Main Results:
- Topical antifungals are effective for many dermatophytosis cases.
- Oral griseofulvin and ketoconazole are options for extensive infections.
- Onychomycosis, T. rubrum sole infections, and certain tinea capitis/corporis forms show resistance.
Conclusions:
- Despite available treatments, some dermatophyte infections present therapeutic challenges.
- Further investigation is needed for optimal treatment duration and frequency.
- Improved drug delivery methods for nails and keratinized tissues are essential for future therapies.
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