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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
14.5K
New insights in Au-NHCs complexes as anticancer agents.
Marina Porchia1, Maura Pellei2, Marika Marinelli2
1CNR-ICMATE, Corso Stati Uniti, 4, 35127 Padova, Italy.
European Journal of Medicinal Chemistry
|February 7, 2018
Summary
Gold(I/III) coordination complexes with N-heterocyclic carbene ligands show promising antiproliferative activity. This review analyzes gold-NHC compounds for cancer treatment, highlighting in vitro efficacy and limited in vivo data.
Area of Science:
- Medicinal inorganic chemistry
- Coordination chemistry
- Cancer research
Background:
- Gold(I/III) complexes are explored as alternatives to platinum-based chemotherapy.
- N-heterocyclic carbene (NHC) ligands have gained prominence in gold medicinal chemistry.
- NHC ligands mimic phosphine properties, enhancing gold complex applications.
Purpose of the Study:
- To review gold(I/III)-NHC complexes as potential antiproliferative agents.
- To analyze in vitro biological data (IC50 values) against chemical structures.
- To summarize the current state of in vivo studies for these compounds.
Main Methods:
- Literature review of gold(I/III)-NHC complexes published between 2004-2016.
- Critical analysis of in vitro antiproliferative activity (IC50 values).
- Evaluation of available in vivo data for selected compounds.
Main Results:
- Numerous gold(I/III)-NHC complexes exhibit significant in vitro antiproliferative activity.
- Structure-activity relationships are explored, linking chemical structure to efficacy.
- A scarcity of in vivo data exists to support the promising in vitro findings.
Conclusions:
- Gold(I/III)-NHC complexes represent a promising class of anticancer agents.
- Further in vivo studies are crucial to validate the therapeutic potential of these compounds.
- This review provides a comprehensive overview of the field's progress and future directions.
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