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[Immunomodulation with apheresis technics].

A Liebert, D Quietzsch, S Zimmermann

    Allergie Und Immunologie
    |January 1, 1986
    PubMed
    Summary
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    Apheresis therapy, including plasmapheresis and cytopheresis, effectively treats immunological diseases like autoimmune disorders and Waldenström

    Area of Science:

    • Immunology
    • Hematology

    Context:

    • Apheresis therapy, encompassing plasmapheresis, plasmafiltration, and cytopheresis, has demonstrated success in managing various immunological conditions.
    • Key indications include autoimmune diseases, immune complex disorders, and paraproteinemias associated with hyperviscosity syndrome, such as Waldenström's macroglobulinemia and plasmocytoma.

    Purpose:

    • To review the successful applications of apheresis in immunological diseases.
    • To outline different apheresis modifications and their indications.
    • To discuss the potential immune-regulatory effects of apheresis therapy.

    Summary:

    • Apheresis therapy is a successful treatment for numerous immunological diseases, particularly autoimmune conditions and paraproteinemias with hyperviscosity.
    • The paper details various apheresis modifications and their clinical uses, exploring potential immune-regulatory mechanisms.

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  • It highlights a shift towards more selective apheresis methods like immunoadsorption and cascade filtration.

    • Impact:

    • Provides a comprehensive overview of apheresis therapy in immunology.
    • Discusses the evolution from non-specific to selective apheresis techniques.
    • Underscores the significance of these advancements for clinical and experimental immunology.