Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glycocalyx and its Functions01:14

Glycocalyx and its Functions

9.1K
The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
9.1K
Circles01:18

Circles

268
A circle in the coordinate plane is defined as the set of all points that lie at a constant distance, known as the radius, from a fixed point called the center. This relationship is captured using the distance formula. For a point (x, y) on the circle and a center (h, k), the distance between them equals the radius r. By squaring both sides of the distance formula, the equation of the circle is written in standard form:Constructing the Equation from Geometric InformationIf the center and the...
268
Mohr's Circle for Moments of Inertia: Problem Solving01:14

Mohr's Circle for Moments of Inertia: Problem Solving

3.3K
Mohr's circle is a graphical method for determining an area's principal moments by plotting the moments and product of inertia on a rectangular coordinate system. This circle can also be used to calculate the orientation of the principal axes.
Consider a rectangular beam. The moments of inertia of the beam about the x and y axis are 2.5(107) mm4 and 7.5(107) mm4, respectively. The product of inertia is 1.5(107) mm4. Determine the principal moments of inertia and the orientation of the major and...
3.3K
Mohr's Circle for Moments of Inertia01:10

Mohr's Circle for Moments of Inertia

1.3K
Mohr's circle is a graphical method to determine an area's principal moments of inertia by plotting the moments and product of inertia on a rectangular coordinate system.
1.3K
Mohr's Circle for Plane Stress01:23

Mohr's Circle for Plane Stress

1.4K
Mohr's circle is a graphical method for identifying the state of stress at a point in a material, making it easier to analyze stress transformations under plane stress conditions. This two-dimensional technique visualizes both normal and shearing stresses on an element.
Consider a set of Cartesian coordinates. The horizontal and vertical axes correspond to normal stress (σ) and shearing stress (τ), respectively. Two points, points A and B, are defined by the normal and shear...
1.4K
Mohr's Circle for Plane Strain01:18

Mohr's Circle for Plane Strain

1.3K
Mohr's circle is a crucial graphical method used to analyze plane strain by plotting strain on a set of cartesian coordinates, where the abscissa is normal strain ∈ and the ordinate is shear strain γ. Similarly to Mohr’s circle for plane stress, two points X and Y are plotted. Their coordinates are (∈x, -γXY) and (∈Y, γXY), respectively.
Mohr's circle visually represents the strain states under various conditions, which is essential for...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Population Inversion and Dirac Fermion Cooling in 3D Dirac Semimetal Cd<sub>3</sub>As<sub>2</sub>.

Nano letters·2022
Same author

CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis.

Pharmacological research·2022
Same author

Activation of the NLRP3 inflammasome by RAC1 mediates a new mechanism in diabetic nephropathy.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2022
Same author

Optimal regenerative repair of large segmental bone defect in a goat model with osteoinductive calcium phosphate bioceramic implants.

Bioactive materials·2022
Same author

Development of Cell-Carrying Magnetic Microrobots with Bioactive Nanostructured Titanate Surface for Enhanced Cell Adhesion.

Micromachines·2021
Same author

Deficiency of IKK<i>α</i> in Macrophages Mitigates Fibrosis Progression in the Kidney after Renal Ischemia-Reperfusion Injury.

Journal of immunology research·2021
Same journal

Airway macrophage specific glycocalyx expression and remodeling following viral infection.

Matrix biology : journal of the International Society for Matrix Biology·2026
Same journal

Cartilage intermediate layer protein (CILP) in cardiac fibrosis: Protective or pathogenic?

Matrix biology : journal of the International Society for Matrix Biology·2026
Same journal

Polymerizing laminins: Assembly, functions and disorders.

Matrix biology : journal of the International Society for Matrix Biology·2026
Same journal

Oligodendrocyte integrin-β1 regulates blood-brain barrier and remyelination in hemorrhagic brain.

Matrix biology : journal of the International Society for Matrix Biology·2026
Same journal

Dynamic regulation of the tissue microenvironment by integrins and the extracellular matrix.

Matrix biology : journal of the International Society for Matrix Biology·2026
Same journal

Corrigendum to "Basement membrane components define the microenvironment of aggregated fibroblasts in the skin and support their aggregation in vitro" [Matrix Biology 146 (2026) 102008].

Matrix biology : journal of the International Society for Matrix Biology·2026
See all related articles

Related Experiment Video

Updated: Feb 14, 2026

Quantifying the Mechanical Properties of the Endothelial Glycocalyx with Atomic Force Microscopy
10:24

Quantifying the Mechanical Properties of the Endothelial Glycocalyx with Atomic Force Microscopy

Published on: February 21, 2013

13.6K

Endothelial cell dysfunction and glycocalyx - A vicious circle.

Xiaohui Zhang1, Dong Sun2, Jeon W Song3

  • 1Department of Bioengineering, Lehigh University, Bethlehem, PA, United States.

Matrix Biology : Journal of the International Society for Matrix Biology
|February 7, 2018
PubMed
Summary
This summary is machine-generated.

Endothelial glycocalyx damage and endothelial cell dysfunction may form a detrimental cycle. Restoring the glycocalyx with novel nanocarriers shows promise for treating cardiovascular, renal, and metabolic diseases.

Keywords:
DiabetesMechanotransductionNitric oxideSheddasesSirtuin 1

More Related Videos

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System
06:12

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System

Published on: September 16, 2025

684
Isolation of Mouse Pancreatic Endothelial Cells
06:14

Isolation of Mouse Pancreatic Endothelial Cells

Published on: June 21, 2024

2.4K

Related Experiment Videos

Last Updated: Feb 14, 2026

Quantifying the Mechanical Properties of the Endothelial Glycocalyx with Atomic Force Microscopy
10:24

Quantifying the Mechanical Properties of the Endothelial Glycocalyx with Atomic Force Microscopy

Published on: February 21, 2013

13.6K
Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System
06:12

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System

Published on: September 16, 2025

684
Isolation of Mouse Pancreatic Endothelial Cells
06:14

Isolation of Mouse Pancreatic Endothelial Cells

Published on: June 21, 2024

2.4K

Area of Science:

  • Cardiovascular Biology
  • Endothelial Cell Biology
  • Biomedical Engineering

Background:

  • Endothelial dysfunction contributes to chronic diseases like cardiovascular, renal, and metabolic disorders.
  • Impaired endothelial glycocalyx is observed in pathological conditions, coinciding with endothelial dysfunction.
  • The interplay between glycocalyx integrity and endothelial function warrants investigation.

Purpose of the Study:

  • To hypothesize a vicious cycle between impaired endothelial glycocalyx and endothelial cell dysfunction.
  • To explore the role of mechanotransduction in this relationship.
  • To propose therapeutic strategies for restoring both components.

Main Methods:

  • Review of physiological and pathological aspects of endothelial mechanotransduction.
  • Analysis of experimental findings supporting impaired mechanotransduction in dysfunctional endothelium.
  • Introduction of liposomal nanocarriers for glycocalyx restoration.

Main Results:

  • Evidence suggests a feedback loop reinforcing endothelial dysfunction and glycocalyx perturbation.
  • Mechanotransduction impairment is linked to dysfunctional endothelia.
  • Liposomal nanocarriers demonstrated rapid restoration of endothelial mechanotransduction.

Conclusions:

  • A vicious cycle likely exists between endothelial glycocalyx damage and endothelial cell dysfunction.
  • Targeting the endothelial glycocalyx offers a therapeutic avenue for chronic diseases.
  • Liposomal nanocarriers represent a promising approach for glycocalyx restoration and functional recovery.