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Updated: Feb 14, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Headache in mitochondrial disorders
Josef Finsterer1, Sinda Zarrouk-Mahjoub2
1Krankenanstalt Rudolfstiftung, Vienna, Austria.
Clinical Neurology and Neurosurgery
|February 7, 2018
Summary
Migraine and migraine-like headaches (MLH) are common in mitochondrial disorders (MIDs). MLH, a secondary headache, may link to stroke-like episodes and requires distinct treatment from migraine.
Area of Science:
- Neurology
- Genetics
- Rare Diseases
Background:
- Headache is a frequent symptom in mitochondrial disorders (MIDs).
- A comprehensive overview of headache in MIDs is lacking.
- Understanding headache patterns is crucial for managing MIDs.
Purpose of the Study:
- To review and discuss headache types, frequency, pathogenesis, and treatment in MIDs.
- To differentiate migraine-like headache (MLH) from other headache types in MIDs.
- To provide insights into the specific management of MLH in MIDs.
Main Methods:
- Literature review summarizing existing studies on headache in MIDs.
- Analysis of headache types, including migraine, MLH, tension-type, and trigemino-autonomic headache.
- Discussion of potential pathomechanisms and treatment strategies.
Main Results:
- Migraine and MLH are the most prevalent headache types in MIDs.
- MLH is a secondary headache, often associated with stroke-like episodes (SLEs) or seizures.
- Treatment for most headaches in MIDs is standard, but MLH may benefit from specific interventions like midazolam, l-arginine, or l-citrulline.
Conclusions:
- Migraine and MLH are key headache manifestations in MIDs.
- MLH presents distinct pathophysiological features compared to migraine, especially when linked to SLEs.
- Tailored treatment approaches are necessary for MLH in MIDs, differing from standard migraine therapy.
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