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Related Concept Videos

Echo01:06

Echo

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The human ear cannot distinguish between two sources of sound if they happen to reach within a specific time interval, typically 0.1 seconds apart. More than this, and they are perceived as separate sources.
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Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

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Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
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Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

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A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
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Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

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Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
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What is an Electrochemical Gradient?01:26

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Accelerators01:17

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Accelerators in concrete serve as admixtures to speed up the hardening process, enabling the concrete to achieve early strength faster. Although accelerators do not necessarily impact the time it takes concrete to set, they reduce this time in practice. A common accelerator is calcium chloride, which is particularly useful for hastening early strength development in cold weather or for rapid repair jobs that require quick heat generation after mixing.
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Gradient Echo Quantum Memory in Warm Atomic Vapor
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Accelerated Parameter Mapping of Multiple-Echo Gradient-Echo Data Using Model-Based Iterative Reconstruction.

Markus Zimmermann, Zaheer Abbas, Krzysztof Dzieciol

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    |February 7, 2018
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    This summary is machine-generated.

    A new method called MIRAGE enhances quantitative magnetic resonance imaging. It provides accurate parameter mapping from multiple-echo gradient-echo (MEGE) data, improving diagnostic capabilities.

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    Area of Science:

    • Medical Imaging
    • Biophysics
    • Signal Processing

    Background:

    • Quantitative magnetic resonance imaging (qMRI) techniques rely on multiple-echo gradient-echo (MEGE) imaging.
    • Accurate parameter mapping is crucial for qMRI applications like water content and susceptibility mapping.
    • Existing reconstruction methods face challenges with speed, robustness, and accuracy.

    Purpose of the Study:

    • To introduce MIRAGE, a novel reconstruction method for MEGE imaging.
    • To achieve accurate, fast, and robust parameter mapping.
    • To enhance the diagnostic utility of quantitative MRI.

    Main Methods:

    • MIRAGE models temporal signals as damped complex exponentials.
    • It employs model-based reconstruction of undersampled data by minimizing Hankel matrix rank.
    • The method integrates multi-channel data and spatial priors, followed by nonlinear regression for parameter estimation.

    Main Results:

    • Simulations and phantom/in vivo data demonstrate MIRAGE's robustness to field inhomogeneity and partial volume effects.
    • MIRAGE significantly improves accuracy compared to the state-of-the-art -ESPIRiT method.
    • Mean absolute error in parameter maps was reduced by up to 50% for in vivo data.

    Conclusions:

    • MIRAGE offers an accurate, fast, and robust solution for MEGE parameter mapping.
    • The method shows superior performance over existing techniques, particularly in challenging conditions.
    • MIRAGE has the potential to advance quantitative MRI and improve diagnostic accuracy.