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Updated: Feb 14, 2026
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Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine
Published on: November 4, 2018
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Hepatocyte Growth Factor Gene Therapy for Ischemic Diseases
Li-Sheng Wang1,2,3, Hua Wang1,2, Qing-Lin Zhang1,2
11 Department of Experimental Hematology, Beijing Institute of Radiation Medicine , Beijing, P.R. China .
Human Gene Therapy
|February 8, 2018
Summary
Hepatocyte growth factor (HGF) gene therapy and modified stem cells show promise for treating ischemic diseases and regenerating tissue. Clinical trials demonstrate the efficacy of HGF gene transfer for critical limb and heart conditions.
Area of Science:
- Regenerative Medicine
- Gene Therapy
- Vascular Biology
Background:
- Ischemic diseases and tissue damage represent significant unmet medical needs.
- Hepatocyte growth factor (HGF) is a key regulator of angiogenesis, inflammation, fibrosis, and tissue regeneration.
- Current therapeutic strategies often have limitations in efficacy and specificity.
Purpose of the Study:
- To review the advances in therapeutic angiogenesis using HGF gene transfer and modified stem cells.
- To explore the physiological roles of HGF in tissue regeneration and angiogenesis.
- To summarize clinical trial progress and future directions for HGF-based regenerative medicine.
Main Methods:
- Review of preclinical experiments and clinical trials on HGF gene therapy.
- Analysis of HGF's physiological functions in angiogenesis and regeneration.
- Examination of clinical data from plasmid and adenovirus HGF trials in China.
Main Results:
- HGF gene therapy has demonstrated feasibility and efficacy in preclinical and clinical settings.
- Clinical trials for critical limb ischemia and coronary heart disease show positive outcomes.
- HGF-modified stem cells offer a promising avenue for novel regenerative strategies.
Conclusions:
- HGF gene therapy is a potent therapeutic approach for ischemic diseases.
- Modified stem cells combined with HGF hold significant potential for regenerative medicine.
- Further research into HGF-based therapies is warranted for improved patient outcomes.
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