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Updated: Aug 5, 2026

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging
Published on: June 29, 2013
Ketanserin, a serotonin S2 antagonist, improved blood flow and skin temperature in patients with micro-vascular ischemic diseases. While effective locally, arterial injection lacked regional specificity.
Area of Science:
- Vascular Medicine
- Pharmacology
Background:
- Micro-vascular ischemic diseases pose significant therapeutic challenges.
- Serotonergic S2 antagonism is a potential therapeutic avenue.
Purpose of the Study:
- To evaluate the efficacy of ketanserin in treating micro-vascular ischemic diseases.
- To assess the impact of intra-arterial ketanserin on limb blood flow and tissue oxygenation.
Main Methods:
- An open-label study involving eleven patients with micro-vascular ischemic diseases.
- Single 10mg intra-arterial dose of ketanserin administered.
- Measurements included limb blood flow, skin temperature, and venous oxygen tension.
Main Results:
- Significant improvement in ipsilateral limb blood flow (50%) and skin temperature (2.5°C).
- Modest elevation in venous oxygen tensions in the affected foot.
- Changes were comparable to chemical sympathectomy outcomes.
Conclusions:
- Ketanserin demonstrates potential in treating micro-vascular ischemic disease.
- Intra-arterial administration showed local efficacy but lacked regional specificity.
- Further research is needed to optimize delivery and assess systemic effects.
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