Related Experiment Video

Updated: Feb 14, 2026

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
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Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Published on: September 14, 2018

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Fate of Antibody-Drug Conjugates in Cancer Cells

Cécile Chalouni1, Sophia Doll2

  • 1Department of Pathology, Genentech, San Francisco, CA, USA. cecilec@gene.com.

Journal of Experimental & Clinical Cancer Research : CR
|February 8, 2018
PubMed

Insights

Antibody-Drug Conjugates (ADCs) are advanced cancer therapies. Understanding their intracellular trafficking and processing is key to improving ADC efficacy and designing next-generation cancer treatments.

Area of Science:

  • Oncology
  • Pharmacology
  • Biotechnology

Background:

  • Antibody-Drug Conjugates (ADCs) represent a significant advancement in cancer therapeutics, merging antibody-driven targeting with potent cytotoxic payloads.
  • Currently, four ADCs are FDA and EMA approved for metastatic conditions, with approximately 60 more in clinical trials, underscoring their growing importance.

Purpose of the Study:

  • This review focuses on the critical intracellular trafficking and processing mechanisms of ADCs.
  • It aims to highlight how these processes influence ADC efficacy and present challenges and opportunities for future ADC design.

Main Methods:

  • A comprehensive literature review was conducted.
  • Key studies on ADC intracellular trafficking, processing, and their impact on cytotoxicity were analyzed.

Main Results:

  • The efficacy of ADCs is critically dependent on the intracellular journey and breakdown of their components to induce tumor cell death.
  • Limited research has explored these essential mechanisms, which are vital for optimizing ADC performance.

Conclusions:

  • Understanding the intracellular mechanisms of ADCs is crucial for overcoming current limitations and advancing their development.
  • This knowledge will guide the rational design of more effective Antibody-Drug Conjugates for cancer treatment.
Keywords:
Antibody-drug conjugatesEndocytic compartmentsEndocytosisIntracellular trafficking

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