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Human cytomegalovirus infection and coronary heart disease: a systematic review

Yu Du1, Guangxue Zhang2, Zhijun Liu3

  • 1Department of Microbiology, Weifang Medical University, Weifang, 261053, China.

Virology Journal
|February 8, 2018
PubMed

Insights

Human cytomegalovirus (HCMV) infection is linked to coronary heart disease and atherosclerosis (AS). Further research is needed to understand HCMV

Area of Science:

  • Cardiovascular Science
  • Infectious Diseases
  • Pathology

Background:

  • Human cytomegalovirus (HCMV) infection has been associated with coronary heart disease since 1987.
  • Studies indicate HCMV-infected endothelial cells contribute to atherosclerosis (AS) development.
  • HCMV susceptibility in patients increases coronary heart disease risk, especially in aging populations.

Purpose of the Study:

  • To review recent studies on the relationship between HCMV infection and coronary heart disease.
  • To explore unresolved questions regarding HCMV's role in atherosclerosis progression.
  • To identify independent factors contributing to viral-induced coronary artery AS.

Main Methods:

  • Review of existing epidemiological and molecular biology studies.
  • Analysis of literature focusing on HCMV infection and cardiovascular conditions.
  • Synthesis of current understanding of viral mechanisms in atherosclerosis.

Main Results:

  • Established association between HCMV infection and atherosclerosis.
  • Evidence suggests HCMV-infected endothelial cells play a role in AS.
  • HCMV infection is a potential risk factor for coronary heart disease.

Conclusions:

  • Further investigation is required to fully elucidate HCMV's role in AS.
  • Understanding viral-induced AS mechanisms is crucial for prevention strategies.
  • Comprehensive knowledge of HCMV infection is necessary for managing cardiovascular risks.
Abstract

Keywords:
Coronary heart diseaseHuman cytomegalovirusInfection

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