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Updated: Feb 14, 2026

Synthesis and Microdiffraction at Extreme Pressures and Temperatures
Published on: October 7, 2013
High hydrostatic pressure in cancer immunotherapy and biomedicine
Irena Adkins1, Nada Hradilova1, Ondrej Palata1
1Sotio a.s, Prague, Czech Republic; Department of Immunology, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czech Republic.
Abstract:
High hydrostatic pressure (HHP) has been known to affect biological systems for >100 years. In this review, we describe the technology of HHP and its effect macromolecules and physiology of eukaryotic cells. We discuss the use of HHP in cancer immunotherapy to kill tumor cells for generation of whole cell and dendritic cell-based vaccines. We further summarize the current use and perspectives of HHP application in biomedicine, specifically in orthopedic surgery and for the viral, microbial and protozoan inactivation to develop vaccines against infectious diseases.
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