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Crosstalk between the Notch signaling pathway and long non-coding RNAs

Andreas Reicher1, Johannes Foßelteder2, Lawrence N Kwong3

  • 1Division of Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria; Research Unit of Non-Coding RNA and Genome Editing in Cancer, Medical University of Graz, 8036 Graz, Austria; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Cancer Letters
|February 8, 2018
PubMed

Insights

Long non-coding RNAs (lncRNAs) regulate the Notch pathway, influencing cancer development. This interaction offers potential biomarkers and RNA-based therapeutic targets for cancer.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • The Notch signaling pathway is crucial for cellular development and implicated in cancer initiation and progression.
  • It influences key cellular processes like differentiation, proliferation, and migration.
  • Pathway outcomes vary based on cellular context and signaling intensity.

Purpose of the Study:

  • To explore the role of long non-coding RNAs (lncRNAs) in regulating Notch signaling.
  • To investigate the interplay between lncRNAs and Notch signaling in cancer.
  • To identify lncRNAs as potential biomarkers and therapeutic targets.

Main Methods:

  • Literature review of recent studies on lncRNAs and Notch signaling.
  • Analysis of molecular mechanisms of lncRNA regulation on Notch pathway components.
  • Examination of lncRNAs as downstream targets and inducers of Notch signaling effects.

Main Results:

  • lncRNAs modulate Notch pathway activity by affecting receptor and ligand expression at transcriptional and posttranscriptional levels.
  • Some lncRNAs are downstream targets of Notch signaling and can promote its oncogenic effects.
  • A complex cross-talk exists between Notch signaling and lncRNAs.

Conclusions:

  • The interaction between Notch signaling and lncRNAs is significant in cancer.
  • lncRNAs are potential biomarkers for assessing Notch signaling activity.
  • These lncRNAs represent promising future targets for RNA-based cancer therapies.
Keywords:
BiomarkerCancerLong non-coding RNANotch signaling pathway

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