Related Experiment Video
Updated: Feb 14, 2026
08:01
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
Published on: February 28, 2017
8.4K
Crosstalk between the Notch signaling pathway and long non-coding RNAs.
Andreas Reicher1, Johannes Foßelteder2, Lawrence N Kwong3
1Division of Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria; Research Unit of Non-Coding RNA and Genome Editing in Cancer, Medical University of Graz, 8036 Graz, Austria; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Cancer Letters
|February 8, 2018
Summary
Long non-coding RNAs (lncRNAs) regulate the Notch pathway, influencing cancer development. This interaction offers potential biomarkers and RNA-based therapeutic targets for cancer.
Area of Science:
- Molecular Biology
- Cancer Research
- Genetics
Background:
- The Notch signaling pathway is crucial for cellular development and implicated in cancer initiation and progression.
- It influences key cellular processes like differentiation, proliferation, and migration.
- Pathway outcomes vary based on cellular context and signaling intensity.
Purpose of the Study:
- To explore the role of long non-coding RNAs (lncRNAs) in regulating Notch signaling.
- To investigate the interplay between lncRNAs and Notch signaling in cancer.
- To identify lncRNAs as potential biomarkers and therapeutic targets.
Main Methods:
- Literature review of recent studies on lncRNAs and Notch signaling.
- Analysis of molecular mechanisms of lncRNA regulation on Notch pathway components.
- Examination of lncRNAs as downstream targets and inducers of Notch signaling effects.
Main Results:
- lncRNAs modulate Notch pathway activity by affecting receptor and ligand expression at transcriptional and posttranscriptional levels.
- Some lncRNAs are downstream targets of Notch signaling and can promote its oncogenic effects.
- A complex cross-talk exists between Notch signaling and lncRNAs.
Conclusions:
- The interaction between Notch signaling and lncRNAs is significant in cancer.
- lncRNAs are potential biomarkers for assessing Notch signaling activity.
- These lncRNAs represent promising future targets for RNA-based cancer therapies.
Related Concept Videos
03:14Notch Signaling Pathway
6.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.6K
02:39lncRNA - Long Non-coding RNAs
10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
02:39lncRNA - Long Non-coding RNAs
3.7K
3.7K
02:57piRNA - Piwi-interacting RNAs
7.7K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.7K
02:33Hedgehog Signaling Pathway
10.2K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.2K
01:19Interactions Between Signaling Pathways
7.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.4K