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Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation
Published on: December 31, 2007
Renewable resources-based approach to biantennary glycolipids
Mojtaba Tabandeh1, Abbas Abdulameer Salman1, Ean Wai Goh1
1Chemistry Department, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Abstract:
A new synthesis approach towards biantennary lipids of Guerbet glycoside type was developed based on oleic acid as sustainable resource. Functionalization of the double bond provided access to primary alcohols with α-branched C19-skeleton. Formulation studies with corresponding lactosides indicated formation of vesicles with high assembly stability. A relatively narrow bimodal size distribution of the latter, which turns into a narrow unimodal distribution of small vesicles upon addition of an ionic cosurfactant, suggests potential for a vesicular drug delivery system.
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