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PDGF/PDGFR axis in the neural systems.

Susmita Sil1, Palsamy Periyasamy1, Annadurai Thangaraj1

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Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are crucial in brain cell functions and development. Dysregulated PDGF/PDGFR signaling contributes to neurodegenerative diseases, offering potential therapeutic targets.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are present in various brain cells, including neurons and glia.
  • PDGF signaling regulates critical central nervous system (CNS) functions like neurogenesis, neuronal development, and cell survival.

Purpose of the Study:

  • To review the multifaceted roles of PDGF/PDGFR signaling in the CNS.
  • To explore the involvement of PDGF/PDGFR signaling in the pathogenesis of neurodegenerative diseases.

Main Methods:

  • Literature review of studies on PDGF/PDGFR signaling in the CNS.
  • Analysis of the implications of PDGF/PDGFR signaling in various neurodegenerative conditions.

Main Results:

  • PDGF/PDGFR signaling exhibits context-dependent, sometimes paradoxical, roles in the CNS.
  • This signaling pathway is implicated in Alzheimer disease, Parkinson disease, ALS, brain cancer, and cerebral ischemia.

Conclusions:

  • Understanding PDGF/PDGFR signaling in the CNS is vital for neurodegenerative disease research.
  • Targeting PDGF/PDGFR pathways may offer novel therapeutic strategies for CNS pathologies.