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The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis

Rebecca Stephens1, Krystle Lim1, Marta Portela2

  • 1Department of Biochemistry and Genetics, La Trobe Institute of Molecular Science, La Trobe University, Melbourne, Victoria, Australia.

Journal of Molecular Biology
|February 8, 2018
PubMed

Insights

The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dlg), and Lethal-2-giant larvae (Lgl) proteins, acts as a tumor suppressor in epithelial cancers. This review explores how these proteins regulate cellular signaling pathways, with disruptions linked to cancer development.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cancer Research

Background:

  • The Scribble cell polarity module (Scrib, Dlg, Lgl) is crucial for cell polarity, tissue homeostasis, and tumor suppression in epithelial cancers.
  • While its role in cell polarity is understood, the precise mechanisms by which Scribble module proteins regulate other cellular processes remain unclear.

Purpose of the Study:

  • To review the protein interactomes of Scrib, Dlg, and Lgl.
  • To elucidate the mechanisms through which these proteins regulate cellular signaling pathways in metazoans.
  • To understand how disruptions in the Scribble module contribute to cancer.

Main Methods:

  • Literature review of studies on Scribble module proteins and their interactomes.
  • Analysis of protein-protein interactions and signaling pathway involvement.
  • Focus on mechanisms of action in metazoan cellular signaling.

Main Results:

  • Scribble module proteins function as scaffolds in regulating diverse signaling pathways.
  • Numerous interacting proteins involved in growth, differentiation, and migration have been identified.
  • Disruption of these pathways is linked to cancer pathogenesis.

Conclusions:

  • Scribble module proteins are key regulators of cellular signaling pathways.
  • Understanding their interactomes and mechanisms is vital for cancer research.
  • Aberrant signaling due to Scribble module dysfunction contributes to epithelial cancers.
Keywords:
Cell polarityCell signalingProtein interactionsScribble moduleTumourigenesis

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