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Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury
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Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury

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Basic fibroblast growth factor enhances cell proliferation in the dentate gyrus of neonatal rats following

Huan Zhu1, Lixing Qiao1, Yao Sun2

  • 1Department of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, Jiangsu Province 210009, China.

Neuroscience Letters
|February 8, 2018
PubMed

Insights

Hypoxic-ischemic insult in newborns can cause brain damage. Basic fibroblast growth factor (bFGF) was found to promote cell proliferation in the hippocampus, offering a potential therapeutic avenue for hypoxic-ischemic brain damage (HIBD).

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pediatrics

Background:

  • Perinatal hypoxic-ischemic insult (HIBD) is a leading cause of infant mortality and neurological deficits.
  • Limited neurotherapeutic options exist for infant HIBD.
  • This study explores neurogenesis and basic fibroblast growth factor (bFGF) in neonatal rat HIBD models.

Purpose of the Study:

  • To investigate the relationship between neurogenesis and bFGF in the hippocampal dentate gyrus (DG) following neonatal HIBD.
  • To determine the role of bFGF in promoting cell proliferation in the DG after HIBD.

Main Methods:

  • Bromodeoxyuridine (BrdU) labeling was used to assess cell proliferation.
  • bFGF's effect on cell proliferation in the DG was examined in neonatal rats post-HIBD.

Main Results:

  • HIBD induced cell proliferation in the hippocampal DG of neonatal rats.
  • bFGF gene expression increased in the hippocampus 7-14 days after HIBD.
  • Exogenous bFGF administration enhanced cell proliferation in the DG following HIBD.

Conclusions:

  • Neonatal HIBD stimulates cell proliferation in the dentate gyrus.
  • bFGF plays a crucial role in promoting this proliferation, suggesting therapeutic potential.
Abstract

Keywords:
Cell proliferationCerebral hypoxiaCerebral ischemiaDentate gyrusNeonatal HIBDbFGF

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