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Updated: Feb 14, 2026

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Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
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Intra-renal splenosis mimicking a solid renal mass.
Ethan A Neufeld1, Simran Sekhon1, Eugenio O Gerscovich1
1Department of Radiology, University of California Davis, Sacramento, CA, USA.
Ultrasound (Leeds, England)
|February 8, 2018
Summary
A solid renal mass in a patient with prior splenectomy may be intra-renal splenosis. Technetium-99m heat-damaged red blood cell scintigraphy confirmed this diagnosis, avoiding invasive procedures.
Area of Science:
- Nephrology
- Radiology
- Nuclear Medicine
Background:
- A young woman presented with an exophytic solid renal mass, initially considered for ablation or partial nephrectomy.
- The patient had a history of splenectomy, prompting consideration of alternative diagnoses beyond typical renal neoplasms.
Observation:
- Ultrasound revealed a homogeneous solid left renal mass.
- The clinical history of splenectomy was a key factor in considering intra-renal splenosis.
Findings:
- Technetium-99m heat-damaged red blood cell scintigraphy definitively diagnosed intra-renal splenosis.
- This non-invasive imaging technique obviated the need for surgical intervention or biopsy.
Implications:
- Intra-renal splenosis should be included in the differential diagnosis for solid renal masses in patients with a history of splenic trauma or splenectomy.
- Nuclear medicine imaging can provide a non-invasive diagnosis, guiding management and avoiding unnecessary procedures.
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