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Updated: Nov 27, 2025

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
19:57

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

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Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities

Philip A May1,2, Christina D Chambers3,4, Wendy O Kalberg2

  • 1University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Chapel Hill.

JAMA
|February 8, 2018
PubMed

Insights

Fetal alcohol spectrum disorders (FASDs) affect 1.1% to 5.0% of first-graders in the US, based on a 2010-2016 study. These findings highlight the need for updated prevalence data on these lifelong disabilities.

Area of Science:

  • Pediatrics
  • Public Health
  • Neuroscience

Background:

  • Fetal alcohol spectrum disorders (FASDs) represent significant, lifelong disabilities with limited current prevalence data in diverse US populations.
  • Previous estimates suggested a prevalence of 10 per 1000 children, but newer, larger-scale studies are needed.

Purpose of the Study:

  • To estimate the prevalence of FASDs, including fetal alcohol syndrome, partial FASD, and alcohol-related neurodevelopmental disorder, across four distinct US regions.
  • To provide updated prevalence figures for FASDs in a contemporary, diverse population sample.

Main Methods:

  • A cross-sectional study employed active case ascertainment from 2010 to 2016, assessing first-grade children across four US communities.
  • Systematic assessment covered four key domains: dysmorphic features, physical growth, neurobehavioral development, and prenatal alcohol exposure.
  • Data were collected from 6,639 first-graders, with analyses focusing on conservative and weighted prevalence estimates.

Main Results:

  • The study identified 222 cases of FASDs among 6,639 first-graders.
  • Conservative prevalence estimates for FASDs ranged from 11.3 to 50.0 per 1000 children (1.1% to 5.0%).
  • Weighted prevalence estimates indicated a range from 31.1 to 98.5 per 1000 children (3.1% to 9.9%).

Conclusions:

  • Estimated FASD prevalence among first-graders in the studied US communities falls between 1.1% and 5.0% using a conservative estimation method.
  • These findings offer more current and potentially accurate US prevalence estimates compared to older data.
  • The generalizability of these estimates to all US communities may be limited.
Abstract

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